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2 resultsUpdated August 16, 2026
1
Expanding the targeted protein degradation approach with small molecule chimeras directed to the 26S proteasome
Nature Communications 17(1) (2026)
Mireia Casasampere; Hector Carneros; Tania Roda; Alice Zuin; Núria Gallisà-Suñé; Alba González-Artero; Bernat Coll-Martínez; José Luis Abad; Abdulateef Alqahtani; Josefina Casas; Patricia Fernández-Nogueira; Antonio Delgado; Jordi Bujons; Gemma Fabriàs; Bernat Crosas
2
Integrated screens reveal that guanine nucleotide depletion, which is irreversible via targeting IMPDH2, inhibits pancreatic cancer and potentiates KRAS inhibition
Gut (2026)
Di Wu; Chunbin Zhu; Haoqi Pan; He Xu; Jin Xu; Yang Liu; Sikai Wang; Mingming Xiao; Xianjun Yu; Si Shi