CrossRef

Design, Synthesis and Antidiabetic Activity of Novel Pyrrole‐3‐Carboximidamide Derivatives as Dipeptidyl Peptidase‐4 Inhibitors

Archiv der Pharmazie 358(8) (2025)

Hossein Fasihi Dastjerdi; Nima Naderi; Amir Garmabdari; Manijeh Nematpour; Melika Ebrahimi; Samaneh Hosseinpoor; Fatemeh Saberinasab; Zahra Sheikholislam; Omid Hosseini; Elham Rezaee; Sayyed Abbas Tabatabai

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Inhibitors of Proteases: A Well-Grounded Strategy in Drug Development

Molecules 30(14) (2025)

Santo Previti; Roberta Ettari

Putative predictive power of baseline cerebrospinal fluid dipeptidyl peptidase-4 on the conversion to secondary progressive multiple sclerosis

Neurological Research (2026)

Nuray Sancar; Sefa Özaydın; Ahmed Serkan Emekli; Vuslat Yılmaz; Recai Türkoğlu; Erdem Tüzün

GPU-Accelerated Virtual Screening and Molecular Dynamics Simulations for Identification of Novel DPP-4 Inhibitors

ACS Omega 11(4) (2026)

Nathaly Vasquez-Martínez; Jonathan Trapala; Laura I. Álvarez-Añorve; Rodolfo A. Lizárraga-Valadez; Martín González-Andrade; Alejandro Sosa-Peinado

Brown adipose tissue: a potential therapeutic target for preventing cardiovascular disease in metabolic disorders

Diabetology & Metabolic Syndrome 17(1) (2025)

Tamara Egan Beňová; Matúš Sýkora; Katarína Ondreják Andelová; Veronika Farkašová; Marek Lepáček; Marta Šoltésová Prnová; Pavel Babál; Dávid Janko; Natália Andelová; Miroslav Ferko; Barbara Szeiffová Bačová

Novel triazole-based piperidine DPP-4 inhibitors with potent anti-diabetic activity: design, synthesis, and biological evaluation

Results in Chemistry 27 (2026)

Yasaman Pourbaba; Pegah Pourshaban; Ali Hashemi; Amir Garmabdari; Zahra Sheikholislam; Leila Bayat; Nima Naderi; Mohammad Mahboubi-Rabbani; Elham Rezaee; Sayyed Abbas Tabatabai

Omarigliptin ameliorates cisplatin-induced renal damage: Cross-talk between glucagon-like peptide-1, HMGB1/RAGE/TLR4 signaling, and TXNIP/NLRP3 inflammasome/gasdermin D axis

Life Sciences 376 (2025)

Shuruq E. Alsufyani; Hany H. Arab; Azza A.K. El-Sheikh; El-Shaimaa A. Arafa; Ahmed Fouad Hussein Hashad; Reham M. Goda; Tamer M. Naguib; Maaly A. Abd Elmaaboud; Mennatallah A. Elkady; Ahmed M. Kabel

Exploring the pharmacological versatility of triazolopyrazine: A multi-target scaffold for drug development

Future Medicinal Chemistry 17(23) (2025)

Debarshi Mondal; Priya Bisht; Preety Kumari; Shiv Kumar; Ghanshyam Das Gupta; Sant Kumar Verma

Potential Molecular Biomarkers for Predicting and Monitoring Complications in Type 2 Diabetes Mellitus

Molecules 30(22) (2025)

Zia Shariat-Madar; Fakhri Mahdi

Unveiling the research directions for pyrrolidine-based small molecules as versatile antidiabetic and anticancer agents

Future Medicinal Chemistry 17(9) (2025)

Shiv Kumar; Rupali Kohal; Debarshi Mondal; Shreya Kumari; Preety Kumari; Priya Bisht; Ghanshyam Das Gupta; Sant Kumar Verma

Design, synthesis, and multi-target biological evaluation of 1,2,3-triazole linked indole–thiazolidinedione hybrids as potent α-glucosidase, α-amylase, and DPP-4 inhibitors with antioxidant potential

Journal of Molecular Structure 1349 (2026)

Anchal Sharma; Rupali Rana; Simranjot Kaur; Nitish Kumar; Karanvir Singh; Anmol Narang; Harmandeep Kaur Gulati; Jyoti; Aanchal Khanna; Kavita Bhagat; Jatinder Vir Singh; Sukhraj Kaur; Chandni Sharma; Preet Mohinder Singh Bedi

Spiropyrrolizine derivatives as multitarget antidiabetic agents in obese type 2 diabetes: integrated in silico , in vitro , and in vivo evaluation of DPP-4 inhibition and hepatic enzyme modulation

Future Medicinal Chemistry 18(7) (2026)

Faiza I. A. Abdella; Dalal Alardan; Ismail Daoud; Nawal S. Alshammari; Ahlam Abdulrahman Alrashdi; Sarra Boudriga

Coumarin derivatives as antidiabetic agents: a comprehensive review on mechanistic insights, structure-activity relationships, in silico studies, and challenges

Future Medicinal Chemistry 18(15) (2026)

Salesh Verma; Sant Kumar Verma

Beneficial Effects of Clitoria ternatea Flower and Citrus limon Fruit Beverage on Nutritional Status, Lipid Profile, and Adipokine Parameters on Male Rats With Obesity

Journal of Obesity 2026(1) (2026)

Fista Utami; Dono Indarto; Shanti Listyawati; Claire Stocker

GLP-1 as a Regulator of Oxidative Signalling in Metabolic Health and Disease

Antioxidants 15(10) (2026)

Natalia Kurhaluk; Renata Kołodziejska; Halina Tkaczenko

Structure-Based in Silico Insights of Sitagliptin Analogs against Dipeptidyl Peptidase-4

Biomedical & Pharmacology Journal 2(19) (2026)

Halah Abdul Sahib

The first examples of monoethyl thioterephthalate containing multiply bonded Re2 complexes with potential antidiabetic activity: A combined experimental and in-silico study

Journal of Molecular Structure 1381 (2027)

Binjazar Ul Haq Islam; Sayoni Dam; Shilpi Chowdhury; Asmita Samadder; Suman Mallick

Pyridazine- and triazine–acetophenone derivatives: synthesis, crystal structure, Hirshfeld surface, DFT analysis, and multitarget docking against DPP-4/CYP7A1/GSK-3β

Journal of Molecular Structure 1368 (2026)

Rana Rudh Pratap Singh; Vipin Kumar; Manisha Nidhar; Nitish Yadav; Niharika Upadhyay; A Rekha; Gaurav Gupta; Deepika Raina; Ashish Kumar Tewari

Unlocking the Potential of Pyrrolidine Derivatives as Antidiabetic Agents: Insights from Physicochemical Analysis, Molecular Docking, ADMET, and DFT Studies

ChemistrySelect 10(37) (2025)

Aeyaz Ahmad Bhat; Jitendra Chaudhary; Gurdeep Kaur; Iqubal Singh

Artificial Intelligence Powered Identification of Potential Antidiabetic Compounds in Ficus religiosa

Journal of Medico Informatics 02(Issue 02) (2026)

Ashad Alam; Md Amanullah

Effect of Kaempferia galanga L. on Xanthine Oxidase Activity and Arterial Stiffness in Hyperuricemia

Tropical Journal of Natural Product Research 9(2) (2025)

Patonah Hasimun; Yoga A. R. Muzaki; Jajang J. Sodik; Ika K. Sukmawati; Herni Kusriani

Dipeptidyl peptidase-4 inhibitors in combination therapy of type 2 diabetes mellitus: Optimal strategies and place in management algorithms

FOCUS. Endocrinology 6(4) (2025)

F. O. Ushanova; T. Yu. Demidova; A. N. Levitskaya

Targeting Gut Microbiota by DPP-4 Inhibitors in Obesity: Mechanistic Insights and Therapeutic Implications

Current Nutrition Reports 15(1) (2026)

Mansour Alanazi; Hayder M. Al-kuraishy; Ahmed A. Mohamed; Shimaa A. Abass; Mustafa M. Shokr; Mubarak Alruwaili; Gaber El-saber Batiha

Unveiling the conformational analysis of N/S-methylene-N/S linked symmetrical scaffolds of 1,2-pyridazinone and 1,2,4-triazinone derivatives: DPP-4 inhibitors

Journal of Molecular Structure 1358 (2026)

Vipin Kumar; Manisha Nidhar; Nitish Yadav; Muhammad Sheraj; Sooraj Sura; Ashish Kumar Tewari

Thiazole heterocycles: a promising scaffold for drug discovery in antidiabetic agent development

Journal of Molecular Structure 1382 (2027)

Gagandeep Kaur; Isha Rani; Vikas Sharma; Parul Sood

Unraveling the Antihyperglycemic Effects of Dipeptyl Peptidase-4 Inhibitors in Rodents: A Multi-Faceted Approach Combining Effects on Glucose Homeostasis, Molecular Docking, and ADMET Profiling

Pharmaceuticals 18(10) (2025)

Raquel N. S. Roriz; Claudia J. P. Cardozo; Gabriela A. Freire; Caio B. R. Martins; Raimundo Rigoberto B. X. Filho; Landerson Lopes Pereira; Gisele F. P. Rangel; Tiago L. Sampaio; Lyanna R. Ribeiro; Gisele Silvestre Silva; Isabelle Maia; Deysi Viviana Tenazoa Wong; Daniele O. B. Sousa; Ariclécio Cunha de Oliveira; Eduardo Reina; Lidia Moreira Lima; Walter Peláez; Matheus Nunes da Rocha; Márcia Machado Marinho; Hélcio Silva dos Santos; Emmanuel Silva Marinho; Jane Eire Silva Alencar de Menezes; Fátima Regina Mena Barreto Silva; Kirley Marques Canuto; Nylane M. N. Alencar; Marisa Jadna Silva Frederico

SM-GAT: a safety-aware multi-task graph attention network for multi-target anti-diabetic lead discovery from natural products

Frontiers in Molecular Biosciences 13 (2026)

Jianxin Zhang; Hongyi Liu; Shengnan Guo