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28 resultsUpdated October 24, 2026

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Potential Molecular Biomarkers for Predicting and Monitoring Complications in Type 2 Diabetes Mellitus

Molecules 30(22) (2025)

Zia Shariat‐Madar; Fakhri Mahdi

Design, synthesis, and multi-target biological evaluation of 1,2,3-triazole linked indole–thiazolidinedione hybrids as potent α-glucosidase, α-amylase, and DPP-4 inhibitors with antioxidant potential

Journal of Molecular Structure 1349 (2025)

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Unveiling the research directions for pyrrolidine-based small molecules as versatile antidiabetic and anticancer agents

Future Medicinal Chemistry 17(9) (2025)

Shiv Kumar; Rupali Kohal; Debarshi Mondal; Shreya Kumari; Preety Kumari; Priya Bisht; Ghanshyam Das Gupta; Sant Kumar Verma

Inhibitors of Proteases: A Well-Grounded Strategy in Drug Development

Molecules 30(14) (2025)

Santo Previti; Roberta Ettari

Omarigliptin ameliorates cisplatin-induced renal damage: Cross-talk between glucagon-like peptide-1, HMGB1/RAGE/TLR4 signaling, and TXNIP/NLRP3 inflammasome/gasdermin D axis

Life Sciences 376 (2025)

Shuruq E. Alsufyani; Hany H. Arab; Azza A. K. El‐Sheikh; El‐Shaimaa A. Arafa; Ahmed Fouad Hussein Hashad; Reham M. Goda; Tamer Mohamed Naguib; Maaly A. Abd Elmaaboud; Mennatallah A. Elkady; Ahmed M. Kabel

Exploring the pharmacological versatility of triazolopyrazine: A multi-target scaffold for drug development

Future Medicinal Chemistry 17(23) (2025)

Debarshi Mondal; Priya Bisht; Preety Kumari; Shiv Kumar; Ghanshyam Das Gupta; Sant Kumar Verma

Brown adipose tissue: a potential therapeutic target for preventing cardiovascular disease in metabolic disorders

Diabetology & Metabolic Syndrome 17(1) (2025)

Tamara Egan Beňová; Matúš Sýkora; Katarína Ondreják Andelová; Veronika Farkašová; Marek Lepáček; Marta Šoltésová Prnová; Pavel Babál; Dávid Janko; Natália Andelová; Miroslav Ferko; Barbara Szeiffová Bačová

Design, Synthesis and Antidiabetic Activity of Novel Pyrrole‐3‐Carboximidamide Derivatives as Dipeptidyl Peptidase‐4 Inhibitors

Archiv der Pharmazie 358(8) (2025)

Hossein Fasihi Dastjerdi; Nima Naderi; Amir Garmabdari; Manijeh Nematpour; Melika Ebrahimi; Samaneh Hosseinpoor; Fatemeh Saberinasab; Zahra Sheikholislam; Omid Hosseini; Elham Rezaee; Sayyed Abbas Tabatabai

Unraveling the Antihyperglycemic Effects of Dipeptyl Peptidase-4 Inhibitors in Rodents: A Multi-Faceted Approach Combining Effects on Glucose Homeostasis, Molecular Docking, and ADMET Profiling

Pharmaceuticals 18(10) (2025)

Raquel Nascimento da Silva Roriz; Claudia Johana Pérez Cardozo; Gabriela Araújo Freire; Caio B. R. Martins; Raimundo Rigoberto Barbosa Xavier Filho; Leon Pereira; Gisele de Fátima Pinheiro Rangel; Tiago Lima Sampaio; Lyanna Rodrigues Ribeiro; Gisele Silvestre da Silva; Isabelle de Fátima Vieira Camelo Maia; Deysi Viviana Tenazoa Wong; Daniele O. B. Sousa; Ariclécio Cunha de Oliveira; Eduardo Reina; Lı́dia Moreira Lima; Walter José PELÁEZ; Matheus Nunes da Rocha; Márcia Machado Marinho; Hélcio Silva dos Santos; Emmanuel Silva Marinho; Jane Eire Silva Alencar de Menezes; Fátima Regina Mena Barreto Silva; Kirley Marques Canuto; Nylane Maria Nunes de Alencar; Marisa Jádna Silva Frederico

Unveiling the conformational analysis of N/S-methylene-N/S linked symmetrical scaffolds of 1,2-pyridazinone and 1,2,4-triazinone derivatives: DPP-4 inhibitors

Journal of Molecular Structure 1358 (2026)

Vipin Kumar; Manisha Nidhar; Nitish Kumar Yadav; Muhammad Sheraj; Sooraj Sura; Ashish Kumar Tewari

GPU-Accelerated Virtual Screening and Molecular Dynamics Simulations for Identification of Novel DPP-4 Inhibitors

ACS Omega 11(4) (2026)

Nathaly Vasquez-Martínez; Jonathan Trapala; Laura I. Álvarez‐Añorve; Rodolfo A. Lizárraga-Valadez; Martín González‐Andrade; Alejandro Sosa‐Peinado

Spiropyrrolizine derivatives as multitarget antidiabetic agents in obese type 2 diabetes: integrated in silico , in vitro , and in vivo evaluation of DPP-4 inhibition and hepatic enzyme modulation

Future Medicinal Chemistry 18(7) (2026)

Faiza I. A. Abdella; Dalal Alardan; Ismail Daoud; Nawal S. Alshammari; Ahlam Abdulrahman Alrashdi; Sarra Boudriga

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Journal of Molecular Structure 1368 (2026)

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Novel triazole-based piperidine DPP-4 inhibitors with potent anti-diabetic activity: design, synthesis, and biological evaluation

Results in Chemistry 27 (2026)

Yasaman Pourbaba; Pegah Pourshaban; Ali Hashemi; Amir Garmabdari; Zahra Sheikholislam; Leila Bayat; Nima Naderi; Mohammad Mahboubi‐Rabbani; Elham Rezaee; Sayyed Abbas Tabatabai

Unlocking the Potential of Pyrrolidine Derivatives as Antidiabetic Agents: Insights from Physicochemical Analysis, Molecular Docking, ADMET, and DFT Studies

ChemistrySelect 10(37) (2025)

Aeyaz Ahmad Bhat; Jitendra Kumar Chaudhary; Gurdeep Kaur; Iqubal Singh

Dipeptidyl peptidase-4 inhibitors in combination therapy of type 2 diabetes mellitus: Optimal strategies and place in management algorithms

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Ушанова Фатима Омариевна; Tatiana Yu. Demidova; A. N. Levitskaya

Sarcopenia and Muscle Metabolism in Cardiovascular–Kidney–Metabolic Syndrome: Pathophysiology, Clinical Implications, and Therapeutic Strategies

Springer eBooks (2025)

Adina Carmen Ilie; Anca Iuliana Pîslaru; Sabinne-Marie Albişteanu; Ioana Dana Alexa

Beneficial Effects of Clitoria ternatea Flower and Citrus limon Fruit Beverage on Nutritional Status, Lipid Profile, and Adipokine Parameters on Male Rats With Obesity

Journal of Obesity 2026(1) (2026)

Fista Utami; Dono Indarto; Shanti Listyawati

Coumarin derivatives as antidiabetic agents: a comprehensive review on mechanistic insights, structure-activity relationships, in silico studies, and challenges

Future Medicinal Chemistry 18(15) (2026)

Salesh Verma; Salesh Verma; Sant Kumar Verma; Sant Kumar Verma

Structure-Based in Silico Insights of Sitagliptin Analogs against Dipeptidyl Peptidase-4

Biomedical & Pharmacology Journal 2(19) (2026)

Halah Abdul Sahib

SM-GAT: a safety-aware multi-task graph attention network for multi-target anti-diabetic lead discovery from natural products

Frontiers in Molecular Biosciences 13 (2026)

Jianxin Zhang; Hongyi Liu; Shengnan Guo

Thiazole heterocycles: a promising scaffold for drug discovery in antidiabetic agent development

Journal of Molecular Structure 1382 (2026)

Gagandeep Kaur; Isha Rani; Vikas Sharma; Parul Sood

GLP-1 as a Regulator of Oxidative Signalling in Metabolic Health and Disease

Antioxidants 15(10) (2026)

Natalia Kurhaluk; Renata Kołodziejska; Галина Михайлівна Ткаченко

The first examples of monoethyl thioterephthalate containing multiply bonded Re2 complexes with potential antidiabetic activity: A combined experimental and in-silico study

Journal of Molecular Structure 1381 (2026)

Binjazar Ul Haq Islam; Sayoni Dam; Shilpi Chowdhury; Asmita Samadder; Suman Mallick

Putative predictive power of baseline cerebrospinal fluid dipeptidyl peptidase-4 on the conversion to secondary progressive multiple sclerosis

Neurological Research (2026)

Nuray Sancar; Şükrü Özaydın; Ahmed Serkan Emekli; Vuslat Yılmaz; Recai Türkoğlu; Erdem Tüzün