The Improvement of Myocardial Function by Granulocyte Colony Stimulating Factor Following Acute Anterior Myocardial Infarction: A Double Blind Placebo Controlled Study

Javad  Kojuri; Alireza  Moaref; Pooyan  Dehghani

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Boards & Committees Indexing and Listing Sources Journal Metrics Publication Ethics and Publication Malpractice Statement Reviewer and AE Registration Form Support Contact Us

APC

Authors Guide Submit Manuscript

The Improvement of Myocardial Function by Granulocyte Colony Stimulating Factor Following Acute Anterior Myocardial Infarction: A Double Blind Placebo Controlled Study

Author(s):

Javad Kojuri^1,*,

Alireza Moaref¹,

Pooyan Dehghani ¹

1Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

International Cardiovascular Research Journal:Vol. 5, issue 2; e13992

Published online:Jun 30, 2011

Article type:Research Article

Received:May 27, 2017

Accepted:Mar 11, 2011

How to Cite:Kojuri J, Moaref A, Dehghani P. The Improvement of Myocardial Function by Granulocyte Colony Stimulating Factor Following Acute Anterior Myocardial Infarction: A Double Blind Placebo Controlled Study. Int Cardiovasc Res J. 2017;5(2):e13992. doi:

Abstract

Background: In patients with acute myocardial infarction (AMI), reperfusion of the occluded infarct-related artery significantly improves acute and late clinical outcome. There is increasing evidence that transplantation of autologous stem cells improves cardiac function after AMI. For propagation of peripheral blood stem cells, application of granulocyte–colony stimulating factor (G-CSF) has been shown to be feasible, effective, and safe.

Methods: Ten patients in the treatment group and 10 patients in the control group were enrolled in this prospective, randomized controlled and double blind study. Two weeks after myocardial infarction that was followed by successful recanalization and stent implantation, the patients of the treatment group received 10 μg/kg body weight per day (divided BID) G-CSF subcutaneously for a maximum duration of 5.0 days. In both groups, ejection fraction was evaluated with echocardiography and cardiac perfusion scans 10 days and 6 months after myocardial infarction. The Tei index was measured by echocardiography.

Results: No severe side effects of G-CSF treatment were observed. There was no significant improvement of left ventricular ejection fraction when the G-CSF treated group was compared to the control group (P=0.821 for cardiac scan and P=0.705 for echocardiography). Changes in Tei index was not significant in the treatment group (P=0.815); however, it was significantly deteriorated in the control group (P=0.005).

Conclusion: In patients with acute anterior myocardial infarction, treatment with G-CSF, is feasible and safe and seems to be effective in improving global cardiac function without affecting the ejection fraction under clinical conditions.

Keywords

Granulocyte–Colony Stimulating Factor

Myocardial Infarction

Fulltext

References

1.
The references are available in PDF.

The Systematic Review and Meta-Analysis of the Efficacy of Granulocyte-Colony Stimulating Factor (G-CSF) in Treatment of Sepsis and Septic Shock

Kiumarth Amini,

Mojtaba Mojtahedzadeh,

Mohamad Rahman Najmeddin,

Aliasghar Tabatabaei Mohammadi

Amini K, Mojtahedzadeh M, Rahman Najmeddin M, Tabatabaei Mohammadi A. The Systematic Review and Meta-Analysis of the Efficacy of Granulocyte-Colony Stimulating Factor (G-CSF) in Treatment of Sepsis and Septic Shock. Compr Health Biomed Stud. 2024;3(2):e161333. doi: https://doi.org/10.5812/chbs-161333

27

Jan

2019

Clinical and Biochemical Effects of Recombinant Human Granulocyte Colony-Stimulating Factor on the Prognosis of Preterm Infants with Early Onset Neonatal Sepsis

Reza Saeidi,

Hossein Akhavan,

Jalil Tavakkolafshari,

Abbas Shapouri-Moghaddam

Saeidi R, Akhavan H, Tavakkolafshari J, Shapouri-Moghaddam A. Clinical and Biochemical Effects of Recombinant Human Granulocyte Colony-Stimulating Factor on the Prognosis of Preterm Infants with Early Onset Neonatal Sepsis. Arch Pediatr Infect Dis. 2019;7(1):e67807. doi: https://doi.org/10.5812/pedinfect.67807

20

Jun

2012

Effects of human Umbilical Cord Stem Cells and Granulocyte Colony- Stimulating Factor (G-CSF) on Carbon Tetrachloride-Induced Nephrotoxicity

Yener Koc,

Mehmet Sokmen,

Abdulkadir Unsal,

Sebnem Cigerli,

Aysim Ozagari,

Taner Basturk

,et al.

Koc Y, Sokmen M, Unsal A, Cigerli S, Ozagari A, et al. Effects of human Umbilical Cord Stem Cells and Granulocyte Colony- Stimulating Factor (G-CSF) on Carbon Tetrachloride-Induced Nephrotoxicity. Nephro-Urol Mon. 2012;4(3):545-550. doi: https://doi.org/10.5812/numonthly.2979

7

May

2014

Granulocyte Colony Stimulating Factor Adjuvant Role on the Immunological Response to Hepatitis B Vaccine in Patients With Cirrhosis: A Double Blind Randomized Placebo Controlled Trial

Kamran Bagheri Lankarani,

Mozaffar Talebzadeh,

Ahad Eshraghian,

Seyed Ali Malek-Hosseini

Bagheri Lankarani K, Talebzadeh M, Eshraghian A, Malek-Hosseini SA. Granulocyte Colony Stimulating Factor Adjuvant Role on the Immunological Response to Hepatitis B Vaccine in Patients With Cirrhosis: A Double Blind Randomized Placebo Controlled Trial. Hepat Mon. 2014;14(5):e15447. doi: https://doi.org/10.5812/hepatmon.15447

22

Jan

2018

Comparison of effect of Nursing Education and Peer Education Methods on Self-Efficacy in Patients with Myocardial Infarction

Reza Mohammadpourhodki,

Mozhgan Rahnama,

Abdolghani Abdollahimohammad,

Aziz Shashraki Vahed,

Morteza Shamsizadeh,

Hosein Shahdadi

Mohammadpourhodki R, Rahnama M, Abdollahimohammad A, Shashraki Vahed A, Shamsizadeh M, et al. Comparison of effect of Nursing Education and Peer Education Methods on Self-Efficacy in Patients with Myocardial Infarction. Mod Care J. 2018;15(1):e56012. doi: https://doi.org/10.5812/modernc.56012

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 1 week ago
Scopus by Title: 1
Last Update: 1 week ago
Scopus by Title (Ref): 1
Last Update: 1 week ago
CrossRef: 0
Last Update: 4 days ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

Javad Kojuri:[PubMed][Scholar]
Alireza Moaref:[PubMed][Scholar]
Pooyan Dehghani :[PubMed][Scholar]

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

Outlines

The Improvement of Myocardial Function by Granulocyte Colony Stimulating Factor Following Acute Anterior Myocardial Infarction: A Double Blind Placebo Controlled Study

Abstract

Fulltext

References

Similar Articles

The Systematic Review and Meta-Analysis of the Efficacy of Granulocyte-Colony Stimulating Factor (G-CSF) in Treatment of Sepsis and Septic Shock

Clinical and Biochemical Effects of Recombinant Human Granulocyte Colony-Stimulating Factor on the Prognosis of Preterm Infants with Early Onset Neonatal Sepsis

Effects of human Umbilical Cord Stem Cells and Granulocyte Colony- Stimulating Factor (G-CSF) on Carbon Tetrachloride-Induced Nephrotoxicity

Granulocyte Colony Stimulating Factor Adjuvant Role on the Immunological Response to Hepatitis B Vaccine in Patients With Cirrhosis: A Double Blind Randomized Placebo Controlled Trial

Comparison of effect of Nursing Education and Peer Education Methods on Self-Efficacy in Patients with Myocardial Infarction

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 4 days ago