The Plausible Predictive Outcome of Intravenous Thrombolysis by High Levels of CRP on Admission in Patients with Myocardial Infarction

Background: Although primary percutaneous transluminal coronary angioplasty is the method of choice for reperfusion in ST-elevation myocardial infarction, the intravenous thrombolysis is a more frequently used method. Thus it is important to identify the risks of reperfusion failure. In this regard, CRP as an inflammatory marker has shown promising value. The aim of this study is to investigate whether CRP level on admission is indicative of intravenous thrombolysis failure.
Methods: This study comprised 84 patients with STEMI. Samples were taken for CRP before initiation of thrombolysis. The correlation of CRP levels with thrombolysis results was investigated at the end of the study.
Results: The study population was divided according to their plasma CRP level on admission. The first group had CRP levels<0.5 mg/L (22 patients) and the second group had CRP levels≥0.5 mg/L (62 patients). There was a statistically significant difference (P=0.01) between the respondents to thrombolysis in the first (59.1%) and second groups (29.0%).
Conclusion: It was demonstrated that patients with low CRP levels on admission showed better response to intravenous thrombolysis while those with high levels of CRP showed unfavorable response.