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International Cardiovascular Research Journal
An annual journal in scientific affiliation with the Cardiovascular Research Center, Shiraz University of Medical Sciences
e-ISSN 2251-9149
p-ISSN 2251-9130
Image Credit:Int Cardiovasc Res J
Outline
The Effects of Omega-3 on Liver Damage after Acute Myocardial Infarction: A Randomized Controlled Clinical Trial
Authors
Ali Alami, Narjes Bahri, Mahmood Nematollahi, Seyed-Hosein Abtahi-Eivary, Abbas Ebadi, Maryam Moghimian, Maryam Moghimian1, Seyed-Hosein Abtahi-Eivary2, Mahmood Nematollahi3, Abbas Ebadi4, Ali Alami5, Narjes Bahri
6,*
6,*1Department of Basic Sciences, School of Medicine, Gonabad University of Medical Sciences, Gonabad, IR Iran
2Department of Biochemistry and Nutrition, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, IR Iran
3Department of Internal Medicine, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, IR Iran
4Department of Medical Emergency, Bohlool Hospital, Gonabad University of Medical Sciences, Gonabad, IR Iran
5Department of Epidemiology and Biostatistics, School of Public Health, Gonabad University of Medical Sciences, Gonabad, IR Iran
6Department of Midwifery, Faculty of Medicine, Social Development and Health Promotion Center, Gonabad University of Medical Sciences, Gonabad, IR Iran
*Corresponding Author: Narjes Bahri Department of Midwifery, Faculty of Medicine, Social Development and Health Promotion Center, Gonabad University of Medical Sciences, Gonabad, IR Iran. Cellphone: +98- 9155000489, Email: nargesbahri@yahoo.com.nargesbahri@yahoo.com
Published online:Mar 01, 2019
Article type:Research Article
Received:Jun 17, 2018
Accepted:Jan 09, 2019
How to Cite:Alami A, Bahri N, Nematollahi M, Abtahi-Eivary S, Ebadi A, et al. The Effects of Omega-3 on Liver Damage after Acute Myocardial Infarction: A Randomized Controlled Clinical Trial. Int Cardiovasc Res J. 2019;13(1):e80953. doi:
Abstract
Background:
Abnormal liver function test results are often observed in patients with acute Myocardial Infarction (MI).
Objectives:
This study aimed to evaluate the effects of omega-3 fatty acids on Alanine Aminotransferase (ALT) activity elevation after MI-induced liver injury.
Methods:
In this randomized clinical trial, 75 patients with acute MI were randomly allocated to an intervention and a control group. The intervention group received 1 gram per day equal to three capsules of Pikasol (fish oil) for three months, while the control group received the routine treatment after MI. In all samples, plasma concentrations of ALT were assessed on the admission day and 2, 30, 60, and 90 days after the intervention. The data were analyzed using the SPSS 16 software, and P < 0.05 was set as the level of statistical significance.
Results:
The results showed no significant differences between the two groups regarding age, sex, Body Mass Index (BMI), and systolic and diastolic blood pressure. The results also indicated no significant differences between the two groups concerning the serum level of ALT on the day of admission (P = 0.68), day 2 (P = 0.79), day 30 (P = 0.86), day 60 (P = 0.09), and day 90 (P = 0.64).
Conclusion:
The study results suggested that the patients receiving omega-3 supplementation following MI had similar ALT levels to those who received no supplementations. However, further studies with larger sample sizes are needed to confirm the results.
Highlights
References
- 1.The references are available in PDF.
Copyright
© 2019, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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