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International Cardiovascular Research Journal
The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences
Outlines
The Association between Thyroid Hormone Levels, and Coronary Slow Flow Phenomenon and Coronary Artery Disease in Euthyroid Patients
Author(s):
Erfan Tasdighi
1, Ali Zahed Mehr2, Arman Karimi Behnagh2, Reza Arefizadeh3, Maziar Gholampour Dehaki4, Zahra Ghaemmaghami5, Mehrzad Gholampour Dehaki1,*1Department of Internal Medicine, School of Medicine, Aja University of Medical Sciences, Tehran, IR Iran
2Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran
3Department of Cardiology, School of Medicine, AJA University of Medical Sciences, Tehran, IR Iran
4Department of Pediatric Cardiac Surgery, Rajaei Cardiovascular Medical and Research Center, Tehran, IR Iran
5Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran
*Corresponding Author: Department of Internal Medicine, School of Medicine, Aja University of Medical Sciences, Tehran, Iran. Tel: +98-21-88028350, Fax: +98-21-86096350, Email: [email protected].[email protected]
Published online:Mar 15, 2020
Article type:Research Article
Received:Nov 02, 2019
Accepted:Jan 27, 2020
How to Cite:Tasdighi E, Zahed Mehr A, Karimi Behnagh A, Arefizadeh R, Gholampour Dehaki M, et al. The Association between Thyroid Hormone Levels, and Coronary Slow Flow Phenomenon and Coronary Artery Disease in Euthyroid Patients. Int Cardiovasc Res J. 2020;14(1):e99310. doi:
Abstract
Background:
Thyroid hormones are well-known for their various effects on the cardiovascular system. However, contradictory results have been obtained regarding the association between thyroid hormones within the Reference Range (RR) and Coronary Artery Disease (CAD). Moreover, scarce evidence is available regarding the association between thyroid hormones and Coronary Slow Flow Phenomenon (CSFP).
Objective:
This study aimed to investigate the relationship between thyroid hormones in the RR, and CSFP and CAD.
Methods:
A total of 1033 euthyroid patients who underwent coronary angiography were enrolled and divided into four groups based on their coronary angiography and Thrombolysis in Myocardial Infarction (TIMI) flow grade: Normal Coronary Artery (NCA), CSFP, Non-obstructive CAD (N-CAD), and Obstructive CAD (O-CAD). Multivariate multinomial regression analysis was conducted to assess the association between thyroid hormone levels and CSFP as well as CAD. Thereafter, the prediction accuracy of Free Triiodothyronine (FT3) levels for the presence of CSFP and CAD was evaluated by the Receiver Operating Characteristic (ROC) curve analysis.
Results:
FT3 serum level was significantly lower in the CSFP and both CAD groups compared to the NCA group (P < 0.001). FT3 level was inversely correlated to the presence of CSFP and CAD (both N-CAD and O-CAD) only in young females. Moreover, TSH was found to be an independent predictor of O-CAD in young individuals, regardless of their gender. Furthermore, FT3 levels ≤ 2.56 pg/mL predicted the presence of CSFP (78% sensitivity and 62% specificity) and FT3 levels ≤ 2.38 pg/mL predicted the presence of CAD (64% sensitivity and 75% specificity) in young females.
Conclusion:
FT3 level was negatively associated with CSFP and CAD in young females. In addition, high levels of TSH were associated with O-CAD only in young patients. Further studies are required to shed more light upon the regarded associations.
References
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Copyright
© 2020, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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