The effects of fluconazole in the treatment of acute biliary pancreatitis

Introduction: Acute biliary pancreatitis is a common disease for the treatment of which antibiotics and antifungal drugs are used simultaneously. Therefore, this study was performed to examine the effects of (mortality and morbidity rates) fluconazole therapy
as an antifungal drug in these patients.
Methods: This study was a random clinical trial. Participants were the hospitalized patients who were suffering from acute pancreatitis gallstones and referred to Imam Reza Kermanshah hospital. Participants were randomly assigned to two groups. In one group a conventional treatment (antibiotics) was received and in the other group conventional treatment regimens with fluconazole (200 mg orally on the first day and then 100 mg daily) was added.
Results: 87.2 % of the sample were female and 12.8 % were male. The average age of the group receiving fluconazole was 25/16 ± 97/53 and the average age in the control group was 43/16 ± 13/54.
The mean duration of hospitalization in patients receiving fluconazole was 10.6 days and 13.6 days for the control group. In the group receiving fluconazole 6/2 % needed surgery and in the control group none. The average length of the stay in the intensive
care unit in the control group was 1.28 and in the fluconazole group was 26.1 days.
Conclusion: As the results of this study showed , administration of oral fluconazole had no effects on mortality, need for surgery, cost, length of the stay in hospital and intensive care units .Therefore, because of the complications and costs of fluconazole, it is recommended that all patients with mild biliary pancreatitis should not being treated with fluconazole. This treating method can be used only for those with fungus in their upper digestive
system secretions.