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Journal of Clinical Research in Paramedical Sciences
The Official Journal of Paramedical School, KUMS
Outlines
The effect of chitosan nanoparticles containing paclitaxel on destruction of breast cancer cells
Author(s):
1Radiation Application Research School, Nuclear Science and Technology Research Institute, Tehran, Iran
2Department of Radiology and Nuclear Medicine, Paramedicine School, Kermanshah University of Medical Sciences, Kermanshah, Iran
*Corresponding Author: Corresponding author: Samira Rasaneh, Radiation Application Research School, Nuclear Science and Technology Research Institute, Tehran, Iran, E-mail: Email: [email protected]
Published online:Jan 05, 2016
Article type:Research Article
Received:Jun 04, 2015
Accepted:Nov 06, 2015
How to Cite: Rasaneh S, Salehi Zahabi S. The effect of chitosan nanoparticles containing paclitaxel on destruction of breast cancer cells. J Clin Res Paramed Sci. 2016;4(4):e82069. doi:
Abstract
Background: Paclitaxel is a new chemotherapy medicine that is used for treating breast, ovarian, and lung cancers as well as AIDS-related Kaposi's sarcoma. Due to the side effects of using this drug, the paclitaxel-loaded chitosan nanoparticles was synthesized and its cytotoxicity effects on breast cancer cell lines was examined.
Methods: The paclitaxel-loaded chitosan nanoparticles were synthesized by the gelation method, purified and isolated in a proper size by centrifugation. The nanoparticles’ size, percentage of loading and releasing time of the drug up to 24 hours and its cytotoxicity effects, compared with Paclitaxel; on breast cancer cell lines were investigated.
Results: Particle sizes revealed to be 248-312 nm using the zetasizer system, the drug loading percentage showed 55±4 %, and the rate of drug releasing time for 24 h measured 5.5 %. On the average in concentration of 0.8 μg/mL the cytotoxicity of the paclitaxol-loaded chitosan nanoparticles was estimated 43% less than that of the taxol.
Conclusion: The results showed that the paclitaxol-loaded chitosan nanoparticles may be considered as a good alternative to taxol since it decreases the related side effects. However, it deserves further investigations in future.
References
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Copyright
© 2016, Journal of Clinical Research in Paramedical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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