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Journal of Clinical Research in Paramedical Sciences
The Official Journal of Paramedical School, KUMS
e-ISSN 2345-3338
p-ISSN 2322-1593
Image Credit:J Clin Res Paramed Sci
Outline
Evaluation of single dose Pregabalin vs. placebo in reducing post– Photorefractive Keratectomy pain
Authors
1Department of Anesthesiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
2Department of Ophthalmology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
3Department of Radiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
4Eye Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
*Corresponding Author: Corresponding author: Nasrin Amiri Fard, Department of Radiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran, E-mail: Email: amirifardnasrin@yahoo.com
Published online:Oct 13, 2014
Article type:Research Article
Received:Mar 09, 2014
Accepted:Aug 14, 2014
How to Cite:Chubsaz M, Daneshgar F, Amiri Fard N, Kazerooni T, Ghaderi E. Evaluation of single dose Pregabalin vs. placebo in reducing post– Photorefractive Keratectomy pain. J Clin Res Paramed Sci. 2014;3(3):e82116. doi:
Abstract
Background: Today, Photorefractive keratectomy (PRK) is one of the most common methods of eye surgery and the most important problem of patient and medical team that are confronted about this surgery is pain. The aim of this study was to determine the
efficacy of Pregabalin for reducing post–photorefractive keratectomy (PRK) pain.
Methods: This study was done as a double blind clinical trial. Patients were divided in two groups (40 patients in each group) as case and control and 30 minute before surgery 150 mg Pregabalin and placebo were prescribed for case and control groups, respectively. In 6, 12 and 24 hours after surgery, pain was measured by Visual Analog Scale (VAS).
Results: The results of this study were showed pain score in 6 and 12 hours after surgery in Pregabalin group was significant lower than control (P<0.001). In Pregabalin group, after 6 hours, 17 patients (42.5%) had VAS score >3 and needs to Acetaminophen;
whereas in control group 33 patients (82.5%) had VAS score >3 (P<0.001). Further, there wasn't any side effect in Pregabalin group.
Conclusion: Our study showed Pregabalin is an effective and with low side effect medicine for reducing of post–photorefractive keratectomy pain.
Highlights
References
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Copyright
© 2014, Journal of Clinical Research in Paramedical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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