Anesthesiology and Pain Medicine
Mahzad Alimian1, 
Farnad Imani1,*, Seyyed Hamid-Reza Faiz1, Alireza Pournajafian1, Seyedeh Fatemeh Navadegi1, Saeid Safari1Post-operative pain and the administration of opioids to relieve it, is considered to be one of the important issues in surgery wards. This issue is even more significant in obese patients, because of the side effects of opioids. Pregabalin is an analog of gamma aminobutyric acid (GABA) which can be effective in dealing with post-operative pain.
This study will consider the effect of oral pregabalin in relieving the pain of obese patients after gastric bypass surgery.
In a double blind clinical trial, 60 candidates for laparoscopic gastric bypass surgery were enrolled in the study through convenience and non-random sequential sampling, into two groups; pregabalin group and control group. Inclusion criteria consisted of: morbid obesity with a body mass index (BMI) > 35, age 1850, American Society of Anesthesiologists (ASA) status I or II, and willingness to take part in the study. Patients in the pregabalin group received 300 mg of oral pregabalin on the morning of the surgery. Post-operative pain was controlled by the patient-controlled intravenous analgesia (PCIA) method, an AutoMed infusion pump containing 20 mg of morphine and normal saline (total volume 100 cc) was administered to all patients after surgery. Patients level of pain were compared by considering their pain intensity on a visual analog scale (VAS), and the occurrence of nausea/vomiting from recovery, until 24 hours after surgery.
A total of 60 patients were compared; 30 patients in each of the pregabalin and control groups. Both groups were similar in age and sex distribution. Mean pain intensity levels during the whole follow up were lower in the pregabalin group than in the control group, up to a maximum of 24 hours after the operation (
The findings of this study indicate that oral pregabalin (300 mg dose) can alleviate patients pain and nausea/vomiting and notably reduce adverse effects.
© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Hassani V, Pazouki A, Nikoubakht N, Chaichian S, Sayarifard A, et al. The Effect of Gabapentin on Reducing Pain After Laparoscopic Gastric Bypass Surgery in Patients With Morbid Obesity: A Randomized Clinical Trial. Anesth Pain Med. 2015;5(1):e61532. doi: https://doi.org/10.5812/aapm.22372
Ziyaeifard M, Mehrabanian MJ, Faritus SZ, Khazaei Koohpar M, Ferasatkish R, et al. Premedication With Oral Pregabalin for the Prevention of Acute Postsurgical Pain in Coronary Artery Bypass Surgery. Anesth Pain Med. 2015;5(1):e24837. doi: https://doi.org/10.5812/aapm.24837
Rao S, S PS, Ramakrishna R. Comparison of Two Preoperative Doses of Pregabalin for Attenuation of Postoperative Pain after Laparoscopic Cholecystectomy. J Cell Mol Anesth. 2021;6(2):e151396. doi: https://doi.org/10.22037/jcma.v6i3.33543
Soltanzadeh M, Ebad A, Pipelzadeh M, Tabatabaei S, Dehghani Firouzabadi M, et al. Gabapentin May Relieve Post-Coronary Artery Bypass Graft Pain: A Double Blind Randomized Clinical Trial. Int Cardiovasc Res J. 2011;5(3):e13826. doi:
Rajappa GC, Vig S, Bevanaguddaiah Y, Anadaswamy TC. Efficacy of Pregabalin as Premedication for Post-Operative Analgesia in Vaginal Hysterectomy. Anesth Pain Med. 2016;6(3):e34591. doi: https://doi.org/10.5812/aapm.34591
Ordering Reprints
Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC
Author(s):
