‌Treatment and recurrence of vaginal candidiasis after oral and intravaginal treatment

Abstract Background: Candida vaginit is one of the most common causes of vaginal discharge. Longterm and unsystematic treatment results in incomplete treatment and recurrent disease. Objective: To evaluate the degree of treatment and recurrence of disease after oral and intravaginal treatment. Methods: The study was conducted on 65 women having vaginal candidiasis. The subjects were randomly divided into 2 groups in which 32 cases received a single oral dose 150 mg of fluconazole and 33 women 200 mg of intravaginal clotrimazole given daily for 3 consecutive days. Favorable clinical response of both groups was measured by Z-test. Findings: No significant difference was observed in favorable clinical response of both groups after one-week treatment. The degree of recurrence of disease in fluconazole and clotrimazole group was 6.9% and 9.7% respectively in which Z-test provided no significant difference in manifestation of symptoms one week and one month after the treatment. Conclusion: The findings indicated the similar effect of oral fluconazole therapy as well as clotrimazole vaginal tablets however, further research is recommended to investigate the recurrence of disease after oral fluconazole therapy.