Comparison of acid salisylic 2% and betamethasone with topical fish oil in recovery of psoriasis signs

Abstract Background: ‍‍‍‍Psoriasis is a chronic skin disease which is treated with wide range of topical and systemic drugs . Most of researchers have approved the effect of oral fish oil in the treatment of psoriasis but any improvement in psoriasis lesion wasn’t seen by others . Objective: To evaluate the effect of topical fish oil versus salisylic acid and betamethasone in treating psoriasis . Methods: This randomized double blind clinical trial was carried out on 39 patients with psoriasis vulgaris. They were randomly divided into two groups The first group (20 patients) were treated with topical salisylic acid and betamethasone . The second group (19 patients) were treated with topical fish oil. The patients were evaluated in beginning and 2 months after treatment. Finally the obtained data were analyzed using SPSS package, t-test, chi-square and paired t-test. Findings: Decrease of erythema and skin lesion size in the first group were more than second group at the end of treatment, but there weren’t significant differences. Decrease of scaling in the first group was more than second group at the end of treatment and this difference was significant (P< 0.05). Conclusion: Topical fish oil is efficient in treatment of psoriasis vulgaris.