The correlation between Helicobacter pylori antibody and hyperemesis gravidarum

¯Abstract Background: Hyperemesis gravidarum is one of the serious complications of pregnancy, which can affect health both in mother and the fetus. Objective: The aim of this study was to evaluate the correlation between Helicobacter pylori antibody and hyperemesis gravidarum. Methods: The present work was a case-control study carried out in Qods hospital, Zahedan, Iran in 2003. Forty patients with hyperemesis gravidarum were compared with 40 normal pregnant females matched with case group for age, gestation time, parity and weight. Blood samples were taken and detection of IgG antibody against Helicobacter pylori was performed using ELISA technique. The data were analyzed by the chi-square and t-tests. Findings: IgG antibody against Helicobacter pylori was positive in 85% of case group and 52. %of control group showing a significant difference statistically (P=0.002). The mean and standard deviation values for antibody in case and control groups were (42.66± 38.13) IU/ml and (21.70± 22.34) IU/ml, respectively. A significant difference was found between two groups (P=0.0026). Conclusion: Based on data found in our study, there is a significant correlation between hyperemesis gravidarum and the presence of IgG antibody against Helicobacter pylori.