Association between Helicobacter Pylori infection and first miscarriage

Introduction: Miscarriage is the most common problem in pregnancy. Major mechanisms responsible for abortion are not always clear. Some underlying factors have been proved. Hence, efforts are being done to determine the new factors like chronic infection. In this study, we investigated relationship between helicobacter pylori (HP) infection and first miscarriage. Materials & Methods: In this study, 70 women with first miscarriage (case group) and 67 with normal (control group) delivery, aged 20-29 years old were studied. Interviews along with 5cc blood were taken from each case to test the specific IgG titer with ELISA method. A questionnaire was filled for each subject. Results: Mean (±SD) age of cases was 23.0±2.6 and control group was 23.8±2.7. This difference was not significant (P=0.076). 45.7% of cases with the first miscarriage and 25.4% control group suffered from HP. Relationship between HP infection and miscarriage was significant (OR=2.48, 95% CI: 1.13-5.46, P=0.013. Conclusion: According to this study, it seems that there is an association between HP infection and first miscarriage. For determining the effect of HP infection on causing the first miscarriage, more studies are required.