The effect of ascorbic acid on serum level of copper, zinc, ceruloplasmin enzyme activity and iron parameters in men

M Tofighi; A Aminpour; M Kimiagar; B. Gloestaan

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

Home

Instructions

Authors Guide Submit Manuscript

Outlines

Abstract
Copyright

The effect of ascorbic acid on serum level of copper, zinc, ceruloplasmin enzyme activity and iron parameters in men

Author(s):

M Tofighi^,*,

A Aminpour,

M Kimiagar,

B. Gloestaan

Journal of Inflammatory Diseases:Vol. 10, issue 1; 36-43

Published online:Jun 30, 2006

Article type:Research Article

How to Cite:Tofighi M, Aminpour A, Kimiagar M, Gloestaan B. The effect of ascorbic acid on serum level of copper, zinc, ceruloplasmin enzyme activity and iron parameters in men. J Inflamm Dis. 2024;10(1):e155185. doi:

Abstract

Abstract Background: Undue use of vitamin C has resulted concerns over some of the harmful effects of it. Objective: To examine the effect of vitamin C on serum level of copper, zinc, iron parameters, and the ceruloplasmin enzyme activity. Methods: This was a double-blind clinical trial carried out in 1999 in Iran Research Institute for Nutrition and Food Sciences in healthy men. Volunteers were divided into 3 groups. Ascorbic acid was given to first two groups at the concentrations of 500mg/day and 1000 mg/day, respectively. No ascorbic acid was delivered to the third group (control group). Fasting blood samples were collected in the beginning and at the end of the study period (6th week). Copper and zinc concentrations were determined by atomic absorption ceruloplasmin enzyme activity and vitamin C levels by colorimetric method iron, TIBC and hemoglobin by employing a kit from zist-chimi company and the percent of transferrin saturation was calculated using the formula: serum iron/TIBC×100. Dietary consumption pattern in the beginning and at the end of the study period were recorded using 24hr dietary recall questionnaire for one day. Findings: Mean Blood ascorbic acid concentration increased by 67% (p=0.001), 76% (0.001), and 23% (p=0.04) in groups marked as 500 mg/day, 1000 mg/day ascorbic acid and control groups, respectively. This was statistically significant at the end of study. Mean ceruloplasmin enzyme activity decreased (p=0.004) in group 1000 mg/day ascorbic acid at the 6th week which was statistically significant. In spite of changes in serum copper and iron levels, these changes were not significant, statistically. Vitamin C had no effect on zinc concentration. No significant change was present in food consumption pattern during the study period. Conclusion: Based on present data, vitamin supplementation at daily doses of 500 and 1000 mg cannot be recommended and further studies are needed in this regard.

Keywords

Effects of oral vitamin C supplement on the serum lipid profile

Mojgan Mohajeri-Iravani,

Ebrahim Hazrati,

Shahram Firuz-Marani Firuz-Marani

Mohajeri-Iravani M, Hazrati E, Firuz-Marani SF. Effects of oral vitamin C supplement on the serum lipid profile. Ann Mil Health Sci Res. 2015;13(1):e62671. doi:

30

Sep

2005

Effect of vitamin C supplements on patients with hypertension

SH Ravanshad,

SH Sadeghi,

MJ . Zibaeinejad,

E Setoudeh Maram,

H Montaseri

Ravanshad S, Sadeghi S, . Zibaeinejad M, Setoudeh Maram E, Montaseri H. Effect of vitamin C supplements on patients with hypertension. J Inflamm Dis. 2024;9(2):e155133. doi:

19

Mar

2006

The Effect of Vitamin C Supplementation on Serum Lipids in Type II Diabetics

AM Ardakani,

E Amirchaghmaghi,

M Modarresi

Ardakani A, Amirchaghmaghi E, Modarresi M. The Effect of Vitamin C Supplementation on Serum Lipids in Type II Diabetics. J Kermanshah Univ Med Sci. 2006;9(4):e81652. doi:

30

Oct

2016

An Overview of the Characteristics and Function of Vitamin C in Various Tissues: Relying on its Antioxidant Function

Abolfazl Akbari,

Gholamali Jelodar,

Saeed Nazifi,

Javad Sajedianfard

Akbari A, Jelodar G, Nazifi S, Sajedianfard J. An Overview of the Characteristics and Function of Vitamin C in Various Tissues: Relying on its Antioxidant Function. Zahedan J Res Med Sci. 2016;18(11):e4037. doi: https://doi.org/10.17795/zjrms-4037

31

Oct

2006

Assessment of Antioxidant Vitamins Retinol and ?- Tocopherol in Plasma and Ascorbic Acid in Plasma and Mononuclear Leukocytes in Type 2 Diabetics

M Firoozrai,

I Nourmohammadi,

K Khanaki

Firoozrai M, Nourmohammadi I, Khanaki K. Assessment of Antioxidant Vitamins Retinol and ?- Tocopherol in Plasma and Ascorbic Acid in Plasma and Mononuclear Leukocytes in Type 2 Diabetics. Int J Endocrinol Metab. 2006;4(4):. doi:

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 2 weeks ago
Scopus by Title: 0
Last Update: 2 weeks ago
Scopus by Title (Ref): 0
Last Update: 2 weeks ago
CrossRef: 0
Last Update: 1 day ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

M Tofighi:[PubMed][Scholar]
A Aminpour:[PubMed][Scholar]
M Kimiagar:[PubMed][Scholar]
B. Gloestaan:[PubMed][Scholar]

The Official Journal of Qazvin University of Medical Sciences

Outlines

The effect of ascorbic acid on serum level of copper, zinc, ceruloplasmin enzyme activity and iron parameters in men

Abstract

Similar Articles

Effects of oral vitamin C supplement on the serum lipid profile

Effect of vitamin C supplements on patients with hypertension

The Effect of Vitamin C Supplementation on Serum Lipids in Type II Diabetics

An Overview of the Characteristics and Function of Vitamin C in Various Tissues: Relying on its Antioxidant Function

Assessment of Antioxidant Vitamins Retinol and ?- Tocopherol in Plasma and Ascorbic Acid in Plasma and Mononuclear Leukocytes in Type 2 Diabetics

Last Update: 2 weeks ago

Last Update: 2 weeks ago

Last Update: 2 weeks ago

Last Update: 1 day ago