Comparison of two-month and four-month effect of vitamin E on cyclic mastalgia

Background: Cyclic mastalgia is a common cause of anxiety among women who visit health care centers. Due to some characters, the administration of proper drugs in treating of cyclic mastalgia is of prime importance. Objective: To compare the two-month and four-month effect of vitamin E on cyclic mastalgia in 20 years-old to premenopausal women. Methods: This was a double-blind randomized clinical trial performed on 150 women who visited three different clinics in Qazvin. The cases were divided into two study and control groups, each consisting of 75 women. Duration and intensity of pain was evaluated by visual analog scale (VAS) and breast pain chart. Daily vitamin E and placebo as chewing pills (200 IU) and for duration of 4 months were given to study and control groups, respectively. The cases were followed up for two and four months. Duration and intensity of pain and drug side-effect was evaluated afterward. Findings: The two-month and four-month administration of vitamin E and placebo caused a reduction in intensity of breast pain. But the four-month consumption of vitamin E in study group was more effective than in control group. The two-month and four-month intake of vitamin E and placebo caused a decrease in duration of breast pain. Again the four-month administration of vitamin E showed a greater effect in study group than in control group. Conclusion: It can be concluded that the administration of vitamin E for four months is an effective therapeutic protocol for cyclic mastalgia with no obvious side effects and could be considered as a suitable substitution for other types of treatment in case of cyclic mastalgia