The Impact of a Resistance Training Period on Lipasin Plasma Level and Lipid and Metabolic Profile in Obese Rats

Background Lipasin is a liver-derived secretory protein; i.e. associated with type 2 diabetes mellitus, obesity, and metabolic syndrome.   Objective The current research assessed the effect of resistance training on atherogenic and metabolic status and lipasin levels in obese rats. Methods In this experimental study, 20 obese rats (8 weeks old, Mean±SD weight: 361±32 g) and 10 normal-weight rats (8 weeks old, Mean±SD weight: 248±13 g) randomly divided into three groups: obese control, obese trained, and control. The obese trained group received an 8-week exercise program for 3 days/week on a specific ladder with a carrying load of 30% of body weight, attached to their tails. The weight of the load was gradually increased during the training sessions, reaching 200% of the body weight of rats in the final week. There were three sets of 5 repetitions with a 3-min rest between each set of exercise sessions and 1 minute between repetitions. Forty-eight hours after the last training session, the blood samples were obtained and analyzed for metabolic status. The collected data were analyzed using analysis of variance (ANOVA), and statistical significance was set at P<0.05.  Findings Lipasin levels were higher in obese rats, than the controls (P=0.02). Atherogenic and metabolic status (TG, TC, LDL, glucose, insulin resistance) were improved in the exercise group, compared to the control group (P=0.05). Plasma lipasin levels were significantly decreased in the obese exercise group (P=0.05).  Conclusion This study indicated that resistance training may be effective in improving metabolic status by decreasing lipasin plasma levels.