High Frequency of Nephropathy Among the Iranian Children and Adolescents With Type 1 Diabetes

Banafsheh Arad; Victoria Chegini; Hoda Hasani; Ali Homaei; Fatemeh Saffari

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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High Frequency of Nephropathy Among the Iranian Children and Adolescents With Type 1 Diabetes

Author(s):

Banafsheh Arad¹,

Victoria Chegini

²,

Hoda Hasani³,

Ali Homaei⁴,

Fatemeh Saffari

^5,*

1Department of Pediatrics, School of Medicine, Children Growth Research Center, Research Institute for Prevention of Non-communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.

2Department of Pediatrics, School of Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran.

4Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

5Children Growth Research Center, Research Institute for Prevention of Non-communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.

Journal of Inflammatory Diseases:Vol. 25, issue 2; 85-92

Published online:Sep 30, 2021

Article type:Research Article

How to Cite:Arad B, Chegini V, Hasani H, Homaei A, Saffari F. High Frequency of Nephropathy Among the Iranian Children and Adolescents With Type 1 Diabetes. J Inflamm Dis. 2024;25(2):e156280. doi:

Abstract

Background: Type 1 Diabetes (T1D) is an autoimmune condition, in which the pancreas produces little or no insulin. Nephropathy is a serious T1D microvascular complication that is associated with high mortality and morbidity. Objective: This study aimed to investigate the prevalence of diabetic nephropathy and comorbidities in children with T1D. Methods: This cross-sectional study was conducted on 208 children (aged 1–18 years old) with T1D who were referred to the Qazvin endocrinology clinic from 2017 to 2019. Anthropometric, demographic, laboratory, and comorbidities data were collected. Results: The Mean±SD age at diagnosis of diabetes was 7.59 years, and the Mean±SD HbA1c level of the study subjects was 8.68±1.42 mmol/mol. Out of 208 diabetic patients, 64 cases (30.7%) had diabetic nephropathy, of whom 53 cases (25.5%) had microalbuminuria and 11 cases (5.3%) had macroalbuminuria. Among the studied diabetic patients, 30 cases (14.45%) had hypothyroidism, 12 patients (5.8%) had celiac disease, and 14 patients (6.7%) had anemia. Retinopathy was not found in any of the patients. Moreover, variables, such as the duration of diabetes, puberty status, mean HbA1c levels, and age were significantly associated with diabetic nephropathy (P<0.05). Conclusion: Mean HbA1c levels were significantly higher in patients with macroalbuminuria, which may corroborate the role of metabolic control of diabetes in the development of albuminuria.

Keywords

Insulin-dependent diabetes mellitus

Nephropathy

Children

Microalbuminuria in Children with Type 1 Diabetes and Its Relationship with Body Mass Index, Hemoglobin A1c, and Age at Diabetes Onset

Asieh Mosallanejad,

Zahra Pournasiri,

Hedyeh Saneifard,

Armin Shirvani,

Maryam Forati

Mosallanejad A, Pournasiri Z, Saneifard H, Shirvani A, Forati M. Microalbuminuria in Children with Type 1 Diabetes and Its Relationship with Body Mass Index, Hemoglobin A1c, and Age at Diabetes Onset. Inn J Pediatr. 2024;34(1):e139616. doi: https://doi.org/10.5812/ijp-139616

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Vijay Tukaram Mali,

Sachin Verma,

Anil Bapurao Kurane,

Nivedita Balasaheb Patil,

Suhas Panditrao Kulkarni

Kavthekar SO, Mali VT, Verma S, Kurane AB, Patil NB, et al. Evaluation of Microalbuminuria and Glycosylated Hemoglobin in the Assessment of Diabetes Control in Children with Type 1 Diabetes Mellitus Hospitalized with Diabetic Ketoacidosis. J Compr Ped. 2021;12(2):e109904. doi: https://doi.org/10.5812/compreped.109904

1

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Microabuminuria in Type 1 Diabetes Mellitus

Z Abdeyazdan,

M Hashemipour,

A Hasanzadeh,

Z Pour Naghshban,

M Kabirzadeh

Abdeyazdan Z, Hashemipour M, Hasanzadeh A, Pour Naghshban Z, Kabirzadeh M. Microabuminuria in Type 1 Diabetes Mellitus. Shiraz E-Med J. 2007;8(1):. doi:

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Prevalence of Celiac Disease in Children with Type 1 Diabetes Mellitus in the South of Turkey

Yasin Sahin,

Meltem Didem Cakir,

Mehmet Isakoca,

Derya Aydin Sahin

Sahin Y, Cakir MD, Isakoca M, Aydin Sahin D. Prevalence of Celiac Disease in Children with Type 1 Diabetes Mellitus in the South of Turkey. Inn J Pediatr. 2019;30(1):e97306. doi: https://doi.org/10.5812/ijp.97306

6

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2016

Prevalence of Metabolic Syndrome in Children With Type 1 Diabetes in South of Iran

Forough Saki

Saki F. Prevalence of Metabolic Syndrome in Children With Type 1 Diabetes in South of Iran. J Compr Ped. 2016;7(3):e37703. doi: https://doi.org/10.17795/compreped-37703

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Author(s):

Banafsheh Arad:[PubMed][Scholar]
Victoria Chegini:[PubMed][Scholar]
Hoda Hasani:[PubMed][Scholar]
Ali Homaei:[PubMed][Scholar]
Fatemeh Saffari:[PubMed][Scholar]

The Official Journal of Qazvin University of Medical Sciences

Outlines

High Frequency of Nephropathy Among the Iranian Children and Adolescents With Type 1 Diabetes

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