Effect of Antioxidant on Sperm Freezing

Maryam Zamani; Fariba Zafari; Vahid Najafzadeh; Farzad Rajaei; mana Kamranjam; Amir Hosseini

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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Effect of Antioxidant on Sperm Freezing

Author(s):

Maryam Zamani,

Fariba Zafari

¹,

Vahid Najafzadeh²,

Farzad Rajaei¹,

mana Kamranjam,

Amir Hosseini^1,*

1Cellular and Molecular Research Center, Research Institute for Presentation of Non-communicable Disease, Qazvin University of Medical Sciences, Qazvin, Iran.

2Queensland Fertility Group Research Foundation, Spring Hill, Queensland, Australia.

Journal of Inflammatory Diseases:Vol. 26, issue 4; 217-226

Published online:Mar 31, 2023

Article type:Review Article

How to Cite:Zamani M, Zafari F, Najafzadeh V, Rajaei F, Kamranjam M, et al. Effect of Antioxidant on Sperm Freezing. J Inflamm Dis. 2024;26(4):e156329. doi:

Abstract

A major cause of male infertility, which includes 50 causes of infertility, is oxidative stress. Aerobic respiration in the sperm cell is associated with the production of reactive oxygen species (ROS). Some reactions, such as sperm capacitation and acrosome reactions require moderate levels of ROS. However, when the amount of ROS production surpasses the natural antioxidant defense of the cell, it causes a harmful effect called oxidative stress. This results in the oxidation of lipids, proteins, carbohydrates, and nucleotides. The production of ROS is increased by various factors, including the presence of leukocytes, sperms with abnormal and immature morphology, centrifugation of samples, and changes in oxygen concentration, pH, and temperature. Sperm freezing is a method widely used in assisted reproductive technology (ART) as well as infertility treatment. The process of freezing also contributes to increased oxidative stress because it alters the fluidity of the mitochondrial membrane, leading to increased production and release of ROS. Sperm have defense mechanisms against oxidative stress caused by increased ROS production, which includes the presence of enzymatic and non-enzymatic antioxidants in semen. The utilization of supplementary antioxidants in the freezing environment is a strategy to combat oxidative stress. This review aims to summarize the current evidence on the effect of antioxidants on sperm freezing.

Keywords

Infertility

Antioxidant

Sperm freezing

Assisted reproductive technics

The Effect of Oxidative Stress and Antioxidants on Men Fertility

Abolfazl Akbari,

gholamali jelodar

Akbari A, jelodar G. The Effect of Oxidative Stress and Antioxidants on Men Fertility. Zahedan J Res Med Sci. 2013;15(7):e92918. doi:

21

Oct

2023

Cysteamine Mitigates the Deleterious Impact of Cryopreservation on Sperm Parameters

Mohammad Amin Behmanesh,

Sima Janati,

Behnam Ghorbanzadeh,

Ahmad Baniasadian,

Seyedeh Mahsa Poormoosavi

Behmanesh MA, Janati S, Ghorbanzadeh B, Baniasadian A, Poormoosavi SM. Cysteamine Mitigates the Deleterious Impact of Cryopreservation on Sperm Parameters. Nephro-Urol Mon. 2023;15(3):e138581. doi: https://doi.org/10.5812/numonthly-138581

31

May

2017

Increasing viability, numbers, and motility of sperm in men with normal spermatogenesis exposed to saffron extract after freezing- thawing process

Y Khazaei,

Sahar Moghbelinejad

Khazaei Y, Moghbelinejad S. Increasing viability, numbers, and motility of sperm in men with normal spermatogenesis exposed to saffron extract after freezing- thawing process. J Inflamm Dis. 2024;21(1):e156006. doi:

30

Jun

2014

Effect of Selenium on the motility, morphology and viability of sperm cells after freezing and thawing procedure

S Nasri,

F Amidi,

Z Rezaeian Movahed

Nasri S, Amidi F, Rezaeian Movahed Z. Effect of Selenium on the motility, morphology and viability of sperm cells after freezing and thawing procedure. J Inflamm Dis. 2024;18(1):e155814. doi:

26

Dec

2015

Antioxidant Effects of Selenium on Seminiferous Tubules of Immature Mice Testis

Davoud Kushki,

Mahnaz Azarnia,

Mohammadreza Gholami

Kushki D, Azarnia M, Gholami M. Antioxidant Effects of Selenium on Seminiferous Tubules of Immature Mice Testis. Zahedan J Res Med Sci. 2015;17(12):e5188. doi: https://doi.org/10.17795/zjrms-5188

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Author(s):

Maryam Zamani:[PubMed][Scholar]
Fariba Zafari:[PubMed][Scholar]
Vahid Najafzadeh:[PubMed][Scholar]
Farzad Rajaei:[PubMed][Scholar]
mana Kamranjam:[PubMed][Scholar]
Amir Hosseini:[PubMed][Scholar]

The Official Journal of Qazvin University of Medical Sciences

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Effect of Antioxidant on Sperm Freezing

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