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3 resultsUpdated October 20, 2026
1

Apremilast attenuates methotrexate-induced hepatic injury in rats; insights into TLR4/NF-κB/P38 MAPK/caspase-3 and α-klotho/Nrf2/HO-1 signaling network interplay

Toxicology and Applied Pharmacology 505 (2025)

Reham H. Mohyeldin; Ehab E. Sharata; Mahmoud Abdelnaser; Ayman M. Ibrahim; Mina Ezzat Attya; Al Shaimaa Mahmoud Kotb; Ahmed S.Aboalela; Remon Roshdy Rofaeil

3

Modulation of AMPK by esomeprazole and canagliflozin mitigates methotrexate-induced hepatotoxicity: involvement of MAPK/JNK/ERK, JAK1/STAT3, and PI3K/Akt signaling pathways

Naunyn-Schmiedeberg's Archives of Pharmacology 398(8) (2025)

Ahmed M. El-Dessouki; Mohamed E. Kaml; Mohammed F. EL-Yamany