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Background:
Theophylline has been shown to cause heart anomaly in animal and human fetus.
Jundishapur Journal of Natural Pharmaceutical Products
The Official Journal of Ahvaz Jundishapur University of Medical Sciences
e-ISSN 2228-7876
p-ISSN 1735-7780
Quercetin Preventive Effects on Theophylline-Induced Anomalies in Rat Embryo
Authors
Neda Sistani Karampour
1,*, Ardeshir Arzi2, Hossein Najafzadeh Varzi3, Babak Mohammadian4, Mohsen Rezaei1
1,*, Ardeshir Arzi2, Hossein Najafzadeh Varzi3, Babak Mohammadian4, Mohsen Rezaei11Department of Pharmacology and Toxicology, School of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, IR Iran
2Department of Pharmacology and Toxicology, Physiology Research Center, School of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, IR Iran
3Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamram University, Ahvaz, IR Iran
4Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamram University, Ahvaz, IR Iran
*Corresponding Author: Department of Pharmacology and Toxicology, School of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, IR Iran. Tel: +98-6113380031, E-mail:, n.sistani1386@yahoo.com. Email: n.sistani1386@yahoo.com
Published online:Jul 31, 2014
Article type:Research Article
Received:Jan 25, 2014
Accepted:Feb 22, 2014
How to Cite:Sistani Karampour N, Arzi A, Najafzadeh Varzi H, Mohammadian B, Rezaei M. Quercetin Preventive Effects on Theophylline-Induced Anomalies in Rat Embryo. Jundishapur J Nat Pharm Prod. 2014;9(3):17834. doi: https://doi.org/10.17795/jjnpp-17834
Abstract
Objectives:
The present study aimed to investigate the protective effect of quercetin on theophylline-induced heart disorders in rat embryo.
Materials and Methods:
Theophylline-induced teratogenicity in rats was used as the animal model. Pregnant rats were administered theophylline (259 mg/kg, po) or theophylline plus quercetin (259 mg/kg, po and 100 mg/kg, ip, respectively) on 9th and 10th days of pregnancy. On day 19, cardiac changes were assessed, measuring malondialdehyde (MDA) and glutathione peroxidase (GPx) activity levels in blood samples and also the fetus heart weight. Histopathological examination was also performed on all specimens.
Results:
Theophylline-treated rats showed MDA level elevation and GPx activity reduction. Quercetin treatment improved heart conditions and resulted in a significant reduction in MDA levels and elevation in GPx activity. Moreover, co-administration of quercetin and theophylline increased the heart weight significantly. Furthermore, histophatological study showed no changes in the treated groups.
Conclusions:
This study demonstrated that quercetin have beneficial effects on theophylline-induced-anomalies in rat embryo.
Highlights
Copyright
© 2014, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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