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Jundishapur Journal of Natural Pharmaceutical Products
The Official Journal of Ahvaz Jundishapur University of Medical Sciences
e-ISSN 2228-7876
p-ISSN 1735-7780
SUSTAINED RELEASE FORMULATION AND IN-VITRO EVALUATION OF IBUPROFEN-HPMC MATRIX TABLETS
Authors
1School of Pharmacy, Ahwaz Jundishapur University of Medical Sciences, Dabbaghma@yahoo.com
2School of Pharmacy, Ahwaz Jundishapur University of Medical Sciences
*Corresponding Author: School of Pharmacy, Ahwaz Jundishapur University of Medical Sciences, Dabbaghma@yahoo.com. Email: Dabbaghma@yahoo.com
Published online:Dec 20, 2006
Article type:Research Article
Received:May 29, 2004
Accepted:Nov 20, 2005
How to Cite:Dabbagh M, Beitmashal L. SUSTAINED RELEASE FORMULATION AND IN-VITRO EVALUATION OF IBUPROFEN-HPMC MATRIX TABLETS. Jundishapur J Nat Pharm Prod. 2006;1(1):. doi:
Abstract
Ibuprofen is one of the safest and most potent non-steroidal anti-inflammatory drug (NSAID) available in the market. To improve the bioavailability of ibuprofen, a thorough preformulation trial was undertaken. As a part of these studies, different formulations of ibuprofen containing different amounts of hydroxypropylmethylcellulose (HPMC) and microcrystalline cellulose (Avicel®) were made and evaluated. The superior formulation which released the drug at constant rate of about 60 mg/hour was chosen. Then the effect of changing particle size of granulation was studied. Two different crystal forms of ibuprofen were prepared and their release pattern were studied. Produced crystal forms of ibuprofen showed different release mechanisms in comparison with the original form. Incorporation of various proportions of tween 80 and Sodium Lauryl Sulfate (SLS) as wetting agent on the release rate of ibuprofen in the formulations were also studied. Sodium lauryl sulphate disintegrated the tablets faster than tween 80.
Highlights
Copyright
© 2006, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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