Journal of Kermanshah University of Medical Sciences
Peer-reviewed Medical Quarterly
e-ISSN 2588-2570
p-ISSN 2588-2562
Image Credit:J Kermanshah Univ Med Sci
Outline
Association between CTLA-4 polymorphism and systemic lupus erythematosus
Authors
Mahdieh Shojaa1, Patricia Khashayar2, Mahsa Amoli3, Mehrdad Aghaie4,*, Mostafa Qorbani5, Mahmoud Akbarian6, Neda Ranjbar Pour7, Arghavan Kouroshnia3
1Deputy of Research and Technology, Golestan University of Medical Sciences, Gorgan, Iran
2Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
3Endocrinology & Metabolism Research Center (EMRC), Tehran University of Medical Sciences, Tehran, Iran
4Dept. of Rheumatology, Faculty of Medicine, Bone Joint and Connective Tissue Research Center (BJCRC), Golestan University of Medical Sciences, Gorgan, Iran
5Dept. of Public Health, Alborz University of Medical Sciencesand Non-communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
6Rheumatology Research Center, Tehran University of Medical Sciences,Tehran, Iran
7Genetic Department, Islamic Azad University, Tehran branch, Tehran, Iran
*Corresponding Author: Corresponding author: Mehrdad Aghaie, Dept. of Rheumatology, Faculty of Medicine, Bone Joint and Connective Tissue Research Center (BJCRC), Golestan University of Medical Sciences, Gorgan, Iran, Tel: +98 9351194232 Email: shojaamahdieh@yahoo.com
Published online:Jan 29, 2014
Article type:Research Article
Received:Jun 30, 2013
Accepted:Oct 29, 2013
How to Cite:Shojaa M, Khashayar P, Amoli M, Aghaie M, Qorbani M, et al. Association between CTLA-4 polymorphism and systemic lupus erythematosus. J Kermanshah Univ Med Sci. 2014;17(10):e74330. doi: https://doi.org/10.22110/jkums.v17i10.1167
Abstract
Background: Cytotoxic lymphocyte antigen-4 (CTLA-4) plays an important role in regulating T cell activities. CTLA-4 gene polymorphisms are associated with genetic susceptibility to various autoimmune diseases, including systemic lupus erythematosus (SLE). The present study was conducted to analyze the role of CTLA-4 polymorphism at positions −1722TC in patients suffering from SLE.
Methods: Samples were collected from 180 SLE patients and 304 healthy people. Both groups were equal in terms of age and ethnicity. Polymerase chain reaction restriction fragments length polymorphism (PCR-RFLP) was used to analyze the genotype and allele frequencies of these polymorphisms. Data were analyzed by SPSS software.
Results: No statistically significant difference was observed between the studied genotypic and allelic frequencies, SLE patients and the controls. There was a significant correlation between age range 15-45 and TT genotype (P<0.0001). However, no significant correlation was found between other risk factors and different genotypes.
Conclusion: The results suggested that 1722TC polymorphism in the promoter region of the CTLA-4 gene does not play any role in the genetic susceptibility to SLE.
Highlights
References
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Copyright
© 2014, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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