Journal of Kermanshah University of Medical Sciences
Peer-reviewed Medical Quarterly
e-ISSN 2588-2570
p-ISSN 2588-2562
Outline
Low dose oral theophylline effects on HS-CRP in stable COPD patients
Authors
1Dept. of Internal Medicine, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
2Dept. of Forensic Medicine, Tehran University of Medical Sciences, Tehran, Iran
3Dept. of Operating Room, School of Para medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
*Corresponding Author: Corresponding author: Naseh Sigari, Dept. of Internal Medicine, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran, Tel: +98 871 3286113 Email: [email protected]
Published online:Nov 19, 2011
Article type:Research Article
Received:Jul 23, 2010
Accepted:Dec 14, 2010
How to Cite:Sigari N, Yousefinejad V, Seidi J. Low dose oral theophylline effects on HS-CRP in stable COPD patients. J Kermanshah Univ Med Sci. 2011;15(4):e79285. doi:
Abstract
Background: Low dose theophylline may have some anti-inflammatory effects on COPD patients. This study was conducted to determine the effect of oral low dose theophylline on serum CRP level in patients with stable COPD.
Methods: In this double blind randomized clinical trail study, 50 patients (25 in experimental and 25 in placebo group) were enrolled into the study by randomized blocking method. Serum HS-CRP using ELISA method was measured before and after the study. Data was analyzed using t-test and paired t-test.
Results: There was no significant difference in gender, age, smoking and spirometry variables before study between two groups. Serum HS-CRP level remained the same between two groups before and after the intervention.
Conclusion: More studies with large sample size needed to find anti-inflammatory effect of theophylline on macrophages and neutrophils and their derivative inflammatory materials in COPD patients.
References
- 1.The references of this article is available on PDF.
Copyright
© 2011, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
Similar Articles
20
Nov
2010
Serum and Saliva Theophylline Levels in Adult Outpatients with Asthma and Chronic Obstructive Pulmonary Disease (COPD): A Cross-Sectional Study
Jamshid Salamzadeh,
Simin Dadashzadeh,
Minoo Habibi,
Salimeh Estifaie
Salamzadeh J, Dadashzadeh S, Habibi M, Estifaie S. Serum and Saliva Theophylline Levels in Adult Outpatients with Asthma and Chronic Obstructive Pulmonary Disease (COPD): A Cross-Sectional Study. Iran J Pharm Res. 2022;7(1):e128574. doi: https://doi.org/10.22037/ijpr.2010.748
3
Jan
2021
A Double-blind Randomized Controlled Trial on the Effects of Montelukast on the Serum Level of Inflammatory Factors in Patients with Chronic Obstructive Pulmonary Disease
Alireza Azargoon,
Ali Kharazmkia,
Nazanin Kordalivand,
Mehdi Birjandi,
Samareh Mir
Azargoon A, Kharazmkia A, Kordalivand N, Birjandi M, Mir S. A Double-blind Randomized Controlled Trial on the Effects of Montelukast on the Serum Level of Inflammatory Factors in Patients with Chronic Obstructive Pulmonary Disease. Shiraz E-Med J. 2021;22(6):e104239. doi: https://doi.org/10.5812/semj.104239
28
Sep
2015
Relationship between complete blood count indices with the severity of disease in patients with chronic obstructive pulmonary disease
Farhad Malek,
Jafar Alaavi Toussy,
Tayebeh Khajeali
Malek F, Alaavi Toussy J, Khajeali T. Relationship between complete blood count indices with the severity of disease in patients with chronic obstructive pulmonary disease. koomesh. 2015;16(2):e151292. doi:
31
Oct
2014
Magnesium Sulfate in Exacerbations of COPD in Patients Admitted to Internal Medicine Ward
Mehrdad Solooki,
Mirmohamad Miri,
Majid Mokhtari,
Morteza Valai,
Mohammad Sistanizad,
Mehran Kouchek
Solooki M, Miri M, Mokhtari M, Valai M, Sistanizad M, et al. Magnesium Sulfate in Exacerbations of COPD in Patients Admitted to Internal Medicine Ward. Iran J Pharm Res. 2014;13(4):e125566. doi: https://doi.org/10.22037/ijpr.2014.1583
29
Jan
2014
Evaluation of the relationship between WBC, HS.CRP and secondary pulmonary hypertension in patients with COPD
Khalil Ansarin,
Farid Rashidi,
Mohammad Reza Ghaffari,
Hossein Namdar,
Akbar Sharifi
Ansarin K, Rashidi F, Ghaffari MR, Namdar H, Sharifi A. Evaluation of the relationship between WBC, HS.CRP and secondary pulmonary hypertension in patients with COPD. J Kermanshah Univ Med Sci. 2014;17(10):e74331. doi: https://doi.org/10.22110/jkums.v17i10.1213
More by these authors
Cited by
- Scopus by DOI: 0
Last Update: 3 weeks ago
- Scopus by Title: 0
Last Update: 3 weeks ago
- Scopus by Title (Ref): 0
Last Update: 3 weeks ago
- CrossRef: 0
Last Update: 6 days ago
Comments
Number of Comments:0