Antibiotic Resistance Pattern of E.coli Isolated from Urine Culture in Imam Reza Hospital Kermanshah-2006

Introduction:  The resistance of pathogenic bacteria to antibiotics has now raised an issue worldwide. As the E.coli is the most common cause of urinary tract and nosocomial infections, the present study was designed to determine the antimicrobial susceptibility of E.coli in the urine culture of patients admitted to Imam Reza Hospital in Kermanshah.

Material and Methods: For this descriptive study, a total of 10492 urine samples were examined during a 12-month period. They were all cultured in EMB,BA,and differential madia , and then examined for E.coli. Antibiogram profile of the bacteria was determined by disk-diffusion test (Kirby-Bauer) according to NCCLS standards.

Results: From 1815 positive samples, 824 came out positive for E.coli. Based on the result of antimicrobial testing resistance to Ampicillin, Co-trimoxazol, Cefixime, Gentamicin, Ceftazidine & Nalidixic acid were 91.4%, 61.1%, 46.8%, 43.3%, 38.8% & 38.5%, respectively. Furthermore Ciprofluxacin, Cefotaxim, Ceftriaxone and Nitrofurantoin had the highest sensitivity at 66.7%, 62.2%, 62.2% &48.8% respectively.

Conclusion: Highest sensitivity was to Ciprofluxacin in this study. Also in clinical practice, it is the first antibiotic prescribed to treat urinary tract infection. In pediatric surgery, Ceftriaxone is a common treatment for which a high sensitivity was observed in this study. The highest resistance belongs to Amplicillin which explains why this drug is not recommended to treat urinary tract infections.