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Journal of Kermanshah University of Medical Sciences
Peer-reviewed Medical Quarterly
Effects of alkylbenzene sulfonate on rat's brain AMP deaminase activity
Author(s):
1Iran
Published online:Sep 19, 2002
Article type:Research Article
Received:Apr 11, 2002
Accepted:Sep 11, 2002
How to Cite:Ghoojagh D, Ghazi Mirsaeed A, Ahanjan M. Effects of alkylbenzene sulfonate on rat's brain AMP deaminase activity. J Kermanshah Univ Med Sci. 2002;6(2):e81004. doi:
Abstract
Introduction and Objective: Alkylbenzene sulfonate is used as surfactant and, being discarded into rivers, it acts as an environmental pollutant. The enzyme AMP deaminase may be potentially useful in delineating the possible mechanisms of biological toxicity of alkylbenzene sulfonate.
Materials and Methods: We studied the effects of alkylbenzene sulfonate on rat's brain AMP deaminase activity by measuring ( with spectrophotometry) the enzyme activity with and without exposure to 5-10 micromole concentrations of alkylbenzene sulfonate, using 30 specimens in each study arm.
Results: Enzyme activity in presence and absence of exposure to alkylbenzene sulfonate was 92.85±8.52 and 18.31±2.45 nmol/min/gr brain protein, respectively.
Discussion and Conclusions: Alkylbenzene sulfonate may inhibit AMP deaminase by reacting to its active site. Our results may be used to understand the toxicity of alkylbenzene sulfonate.
Copyright
© 2002, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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