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Journal of Kermanshah University of Medical Sciences
Peer-reviewed Medical Quarterly
e-ISSN 2588-2570
p-ISSN 2588-2562
Efficacy of Hydroxy urea in Thalassemia intermedia
Authors
1Iran
Published online:Dec 19, 2002
Article type:Research Article
Received:Aug 12, 2002
Accepted:Dec 11, 2002
How to Cite:Ehsaani M, HedaayatiAsl A, Baagheri A. Efficacy of Hydroxy urea in Thalassemia intermedia. J Kermanshah Univ Med Sci. 2002;6(3):e81014. doi:
Abstract
Introduction and Objectives: There is some controversy over the clinical efficacy of Hydroxy urea in Thalassemia intermedia.
Materials and Methods: Therapeutic efficacy of Hydroxy urea was evaluated in 16 patients with thalassemia intermedia, by measuring total hemoglobin and hemoglobin F levels before and 6months after treatment with Hydroxy urea (20mg/kg/day).
Results: Mean increases in total hemoglobin and hemoglobin F levels 6mo after treatment with Hydroxy urea were 1.47±1.12gm/dl and 1.43±1.12 gm/dl, respectively. The most common mutation was found to be IV S II-I betaglobin.
Discussion and Conclusions: Use of Hydroxy urea in thalassemia intermedia is associated with increases in total hemoglobin and hemoglobin F levels.
Highlights
Copyright
© 2002, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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