Evaluation of the Therapeutic Effect of Achillea wilhelmsii C. Koch Aqueous Extract in Acetic-acid-induced Ulcerative Colitis in Rat

Ali Ghobadi; Mohammad Heydarian; Gholamreza Bahrami; Leila Hosseinzadeh; Yalda Shokoohinia; MohammadHossein Farzaei; Hosna Khazaei; Kimia Aghaei

doi:10.4103/jrptps.JRPTPS_4_20

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Abstract
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https://doi.org/10.4103/jrptps.JRPTPS_4_20

Evaluation of the Therapeutic Effect of Achillea wilhelmsii C. Koch Aqueous Extract in Acetic-acid-induced Ulcerative Colitis in Rat

Author(s):

Ali Ghobadi¹,

Mohammad Heydarian²,

Gholamreza Bahrami²,

Leila Hosseinzadeh²,

Yalda Shokoohinia²,

MohammadHossein Farzaei

^2,*,

Hosna Khazaei

²,

Kimia Aghaei²

1Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran

2Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 10, issue 1; 29-34

Published online:May 31, 2021

Article type:Research Article

Received:Jan 07, 2020

Accepted:Sep 10, 2020

How to Cite:Ghobadi A, Heydarian M, Bahrami G, Hosseinzadeh L, Shokoohinia Y, et al. Evaluation of the Therapeutic Effect of Achillea wilhelmsii C. Koch Aqueous Extract in Acetic-acid-induced Ulcerative Colitis in Rat. J Rep Pharm Sci. 2021;10(1):e146977. doi: https://doi.org/10.4103/jrptps.JRPTPS_4_20

Abstract

Context: Ulcerative colitis (UC) is a chronic, idiopathic, and recurrent disease with unknown etiology. Achillea wilhelmsii has been introduced as a herbal remedy for gastrointestinal ulcers and UC in traditional Persian medicine.
Aims: We examined the effectiveness of A. wilhelmsii aqueous extract against acetic-acid-induced UC in rats.
Settings and Design: Fifty-six male Wister albino rats weighing 180–200 g were randomly divided into eight groups and after induction of UC were treated with five doses of aqueous extract of A. wilhelmsii.
Materials and Methods: After induction of UC by acetic acid, the aerial parts of A. wilhelmsii (6.25, 12.5, 25, 50, and 100 mg/kg) were administered orally. On 11th day, the animals were euthanized by overdose of ether inhalation and the intestinal tissue was rapidly dissected for macroscopic, histological, and microscopic scores.
Statistical Analysis Used: Data were analyzed by stats Directver.2.7.9 (SAS, Cary, North Carolina). One-way analysis of variance (ANOVA) followed by Newman–Keul’s post hoc test for multiple comparisons. A value of P < 0.05 was considered as significant level. Results were expressed as mean ± standard error of the mean (SEM).
Results: All doses of A. wilhelmsii extract significantly reduced macroscopic and microscopic scores of colitis without significant changes in bodyweight of animals.
Conclusions: Treatment of the rats with A. wilhelmsii extract improved UC via its anti-inflammatory, antioxidant, and antimicrobial activities. According to the results of this study, A. wilhelmsii has a therapeutic effect against acetic-acid-induced UC in the animal model.

Keywords

Achillea wilhelmsii C. Koch

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Author(s):

Ali Ghobadi:[PubMed][Scholar]
Mohammad Heydarian:[PubMed][Scholar]
Gholamreza Bahrami:[PubMed][Scholar]
Leila Hosseinzadeh:[PubMed][Scholar]
Yalda Shokoohinia:[PubMed][Scholar]
MohammadHossein Farzaei:[PubMed][Scholar]
Hosna Khazaei:[PubMed][Scholar]
Kimia Aghaei:[PubMed][Scholar]

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Evaluation of the Therapeutic Effect of Achillea wilhelmsii C. Koch Aqueous Extract in Acetic-acid-induced Ulcerative Colitis in Rat

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