Journal of Reports in Pharmaceutical Sciences
Synthesis and Comparison of Anti-Leishmania major Activity of Antimony and Iron Complexes of 3-Hydroxypyran-4-One and 3-Hydroxypyridine-4- One as Bi-Dentate Ligands
Abstract
Background: Leishmaniasis infection threatens millions of people in under developing and developing countries. Treatment of this neglected disease is very complicated.
Subjects and Methods: A novel series of antimony (V) complexes using bidentate ligands of hydroxypyranones and hydroxypyridinones have been designed and synthesized. For the synthesis of the complexes, SbCl5 in water was added to the solution of each ligand at 60°C and the pH of mixture was adjusted to 8 using aqueous NaOH. After 24 h stirring, extraction of produced compound into acetone gave the desired complex. The structure of complexes was achieved by using FTIR, 1HNMR, and electron spin ionization mass spectroscopic techniques. All compounds were evaluated for in vitro anti amastogote form of Leishmania major.
Results and Conclusion: The most potent antimony complexes against amastigotes were 5b (after 48 and 72 h) and 5a (after 72 h) with IC50 values of 24.4, 16.3, and 30.1 μg/mL, respectively. Furthermore, antimony and iron complexes were used together for in vitro anti amastigote form of L. major activity. These compounds were toxic for macrophages and destroyed them.
Copyright
© 2020, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
Sb(V) Kaempferol and Quercetin Derivative Complexes: Synthesis, Characterization and Antileishmanial Activities
Abdeyazdan S, Mohajeri M, Saberi S, Mirzaei M, Ayatollahi SA, et al. Sb(V) Kaempferol and Quercetin Derivative Complexes: Synthesis, Characterization and Antileishmanial Activities. Iran J Pharm Res. 2022;21(1):e128379. doi: https://doi.org/10.5812/ijpr-128379
Design, Synthesis and Antitubercular Evaluation of Novel Series of Pyrazinecarboxamide Metal Complexes
Ali M, Ahmed M, Hafiz S, Kamal M, Mumtaz M, et al. Design, Synthesis and Antitubercular Evaluation of Novel Series of Pyrazinecarboxamide Metal Complexes. Iran J Pharm Res. 2018;17(1):e124741. doi: https://doi.org/10.22037/ijpr.2018.2185
Hydroxypyridinone Derivatives: Synthesis And Cytotoxic Evaluation
Sadeghi-Aliabadi H, Saghaie-Aliabadi L, Tadayonnia N, Mirian M. Hydroxypyridinone Derivatives: Synthesis And Cytotoxic Evaluation. J Rep Pharm Sci. 2013;2(1):e147757. doi:
Synthesis, Spectroscopic Characterization, Coordination, and Antimicrobial Activity of Some Metal Complexes Derived From 1, 2-Diphenylethane-1, 2-dione and Dinitrophenyl Hydrazine Schiff Base Ligand
Gull P, Ikbal Ahmad Talukdar M, Ahmad Dar O, Ahmad Malik M, Adil Hashmi A. Synthesis, Spectroscopic Characterization, Coordination, and Antimicrobial Activity of Some Metal Complexes Derived From 1, 2-Diphenylethane-1, 2-dione and Dinitrophenyl Hydrazine Schiff Base Ligand. Jundishapur J Nat Pharm Prod. 2018;13(1):e67179. doi: https://doi.org/10.5812/jjnpp.67179
The In Vitro Effect of Hydroalcoholic Extract of Artemisia absinthium on the Growth of Leishmania major (MRHO/IR/75/ER) in Peritoneal Macrophages from BALB/c Mice
Rahiminejad A, Hazrati Tappeh K, Seyyedi S, Mikaili P. The In Vitro Effect of Hydroalcoholic Extract of Artemisia absinthium on the Growth of Leishmania major (MRHO/IR/75/ER) in Peritoneal Macrophages from BALB/c Mice. Jundishapur J Microbiol. 2018;11(11):e77302. doi: https://doi.org/10.5812/jjm.77302
Crossmark
Checking
- Scopus by DOI: 5
Last Update: 1 month ago
- Scopus by Title: 5
Last Update: 1 month ago
- Scopus by Title (Ref): 5
Last Update: 1 month ago
- CrossRef: 5
Last Update: 5 days ago
Ordering Reprints
Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC
Author(s):