Journal of Semnan University of Medical Sciences
Therapeutic effects of fludarabine-cyclophosphamide combined therapy in Iranian patients with B-cell chronic lymphocytic leukemia
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,*Abstract
Introduction: The aim of this study was to investigate the efficacy of fludarabine-cyclophosphamide combination in treatment of Iranian patients with B-cell chronic lymphocytic leukemia (B-CLL). Materials and Methods: Between April 2011 and July 2013, 20 patients with B-CLL (median age 63 years) received a regimen that consisted of fludarabine 25 mg/m2 and cyclophosphamide 250 mg/m2, days 1-3, orally, every 4 weeks, for a maximum of 6 courses. Clinical appearances and percentage of CD5+/CD19+ cells as minimal residual disease detected by flow cytometry before and 6 months after treatment. Results: The frequency of CD5+, CD5+/CD19+ and CD19+-cells were significantly high (70-90 %) in the peripheral blood of all the patients, before treatment. The percentage of CD2 and CD3+-cells were significantly increased after treatment (p
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© 2015, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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