Therapeutic effects of Curcumin on renal tissue damages induced by ischemia reperfusion in rat

 Introduction: Curcumin has anti-inflammatory and anti-oxidative properties, and the aim of this study was to investigate the therapeutic effects of Curcumin on tissue damages induced by renal ischemia/ reperfusion. Materials and Methods: In this research, male Wistar rats were studied in 9 groups which were include sham with 24h reperfusion period, ischemia followed by 24h reperfusion, ischemia/reperfusion-24h which received a single dose 10, 20, or 30 mg/kg (i.p), Curcumin 30 min after ischemia, sham with 72h reperfusion period, ischemia followed by 72h reperfusion, ischemia/reperfusion-72h which received a single dose 20 mg/kg (i.p), Curcumin and ischemia/reperfusion-72h which received three doses of Curcumin (20 mg/kg, i.p) every 24 hours. At the end of reperfusion period, the left kidney tissue were collected and after staining with hematoxylin-eosin, subjected to microscopic study. Results: Ischemia/reperfusion leads to increased Bowman's space size, tubular necrosis, vascular congestion and intra-tubular proteinaceous casts in kidney which Curcumin therapy could partially improve all of them. But its effect in groups with 72h reperfusion period and receiving 3 dose of Curcumin was significantly greater than those received single dose and 24h reperfusion in comparison with their own sham groups. Conclusion: The results of this study demonstrated that three successive doses of curcumin can be more effective than single-dose treatment on tissue damages resulting from renal ischemia/ reperfusion in rat