The effect of denervation on the response of burn wounds to herbal fundermol ointment in rat

Introduction, T he re a re several r e por t s on the therapeutic effects of herbal fund errn ol ointment in burn wounds. The aim of this investigation was to evaluate the effect of denervation on the response of rat burn wounds to this ointment and com pare its effect with intact animal. Material and Methods, This experimental study performed on the six groups of adult male rats . After aneas thesia, small burn was produced on the hind limb of the rats, by the heated metal device. After aneasthesia, denervation were made on the hind limb by sci atic and femoral nerve neurotomy. 24 hours after burn, fundermol ointment a nd sulfadiazine cream were topically appllied wound surface. Area, percentage of wound healing, angiogenesis growth of ha ir follicules were measured in differen t post-burn days. Results, The results show that percentage of wound healing in denervated gro up was the same as the group cont rol. In the fundermol tre ated denervated group, percentage of wound healing at days 12, 15, 18, 21, 24, 27, and 30 of post-burn period, was more than denervated group (P < O.OOI ) . Percentage of wound healing in the silver slu fadiazine -treated denervated group in 9th to 30th days was highe r th an denerva ted group (P