Koomesh
Journal of Semnan University of Medical Sciences
Systemic administrations of Bombesin modulate acute pain in mice
Abstract
Introduction: Bombesin (BBS) is a tetra-decapeptide, which is widely distributed in mammalian central nervous system. Due to presence of BBS in neural pathways that involved in control of pain, the aim of this study was to test the effects of this peptide on acute pain in mice. Materials & Methods: Male albino mice (25-30 gr.) were used in this study. Hot plate (HP) and Tail Flick (TF) models were applied for the evaluation of BBS effects on acute pain. Five minute prior to measuring pain, different doses of BBS (1.25, 2.5, 5, 10 and 20 µg/kg) or saline were respectively injected to test and control animals by the route of intraperitoneal. Results: The results of current study indicated that peripheral injection of BBS produces significant analgesic effects in both TF and HP models. Conclusion: The present data provide evidences that BBS plays an important role in control of acute pain. Further studies are required to determine the underlying mechanisms.
Copyright
© 2006, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
Evaluation of Antinociceptive Effect of Pregabalin in Mice and its Combination with Tramadol using Tail Flick Test
Keyhanfar F, Shamsi Meymandi M, Sepehri G, Rastegaryanzadeh R, Heravi G. Evaluation of Antinociceptive Effect of Pregabalin in Mice and its Combination with Tramadol using Tail Flick Test. Iran J Pharm Res. 2013;12(3):e125690. doi: https://doi.org/10.22037/ijpr.2013.1340
Role of brain-derived neurotrophic factor receptor on the anxiety levels in rats following the acute administration of morphine
Khalil-Khalili M, Ghodrati-Jaldbakhan S, Rashidy-Pour AL, Bandegi AR, Yousefi B, et al. Role of brain-derived neurotrophic factor receptor on the anxiety levels in rats following the acute administration of morphine. koomesh. 2016;17(3):e151221. doi:
Preventive effects of progesterone against neuropathic pain responses in a rat model of chronic constriction injury
Jarrahi M, Hasani R, Rashidy-Pour AL, Safakhah HA. Preventive effects of progesterone against neuropathic pain responses in a rat model of chronic constriction injury. koomesh. 2019;21(1):e153053. doi:
Effect of Acute and Chronic Administration of Carbamazepine on Cisplatin-Induced Hyperalgesia in Rats
Mohajjel Nayebi A, Sharifi H, Ramadzani M, Rezazadeh H. Effect of Acute and Chronic Administration of Carbamazepine on Cisplatin-Induced Hyperalgesia in Rats. Jundishapur J Nat Pharm Prod. 2012;7(1):27-30. doi: https://doi.org/10.17795/jjnpp-3559
Effect of Probiotic Administration on Acute Inflammatory Pain
Shadnoush M, Nazemian V, Manaheji H, Zaringhalam J. Effect of Probiotic Administration on Acute Inflammatory Pain. Middle East J Rehabil Health Stud. 2017;4(1):e42022. doi: https://doi.org/10.17795/mejrh-42022
- Scopus by DOI: 0
Last Update: 0 months ago
- Scopus by Title: 0
Last Update: 0 months ago
- Scopus by Title (Ref): 0
Last Update: 0 months ago
- CrossRef: 0
Last Update: 4 days ago
Ordering Reprints
Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC
Author(s):