Journal of Semnan University of Medical Sciences
The effect of sex steroid hormones on brain edema and intracranial pressure after experimental traumatic brain injury in rats
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Abstract
Introduction: We investigated the role of sex hormones on changes in brain edema intracranial pressure (ICP), cerebral perfusion pressure (CCP) after trauma brain injury (TBI) in ovarectomized female (OVX) rats. Material and Methods: In this study female rats are divided into five groups. Control group (Intact) sham group and other groups include: vehicle, estrogen group (1mg/kg) and progesterone group (8 mg/kg) which on all groups TBI was induced by Marmarou method. 30 minutes after TBI, drugs were injected i.p. ICP was measured in spinal cord using a standard procedure. CPP was calculated by the mean arterial pressure (MAP) - ICP. Neurologic scores were measured by motor, eye and respiratory reflex Results: The results showed after TBI, water content was significantly lower in estrogen and progesterone groups (P
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© 2024, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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