Journal of Semnan University of Medical Sciences
Effects of different phases of estrous cycle on brain edema and neurological outcomes after severe traumatic brain injury in female rats
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Abstract
Introduction: Sex is one of the main recovery parameters after traumatic brain injury (TBI). During estrus cycle phase, plasma estrogen and progesterone levels are very different. So in this study, we have assessed different effects of these phases in brain edema and neurological outcomes. Materials and Methods: Adult female Albino-N-MARI rats were divided into 6 groups (14 per group) including metestrus, diestrus, proestrus, estrus, ovarictomized (OVX) rats, and sham group (without TBI and ovary). In all groups, brain water content for the measurement of brain edema, evans blue content for the measurement of brain vascular permeability, neurological scores, plasma estrogen and progesterone levels were assessed after severe TBI. Results: Brain water content in diestrus, proestrus and estrus groups showed a significant decrease as compared with OVX group (P
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© 2011, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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