Induction of apoptotic and anti-proliferative effects in REH cells upon neurokinin-1 receptor inhibition using Aprepitant

Author(s):
Elham RazaniElham Razani, A. va Safaroghli-AzarA. va Safaroghli-Azar, Davood BashashDavood Bashash,*

Koomesh:Vol. 20, issue 4; 748-755
Published online:Mar 30, 2018
Article type:Research Article
Received:Nov 08, 2017
Accepted:Mar 01, 2018
How to Cite:Razani E, Safaroghli-Azar AV, Bashash D. Induction of apoptotic and anti-proliferative effects in REH cells upon neurokinin-1 receptor inhibition using Aprepitant. koomesh. 2018;20(4):e153022. doi:

Abstract

References

  • 1.
    Harrison CJ. Targeting signaling pathways in acute lymphoblastic leukemia: new insights. Hematology Am Soc Hematol Educ Program 2013; 2013: 118-125.
  • 2.
    Hinze L, Mricke A, Zimmermann M, Junk S, Cario G, Dagdan E, et al. Prognostic impact of IKZF1 deletions in association with vincristinedexamethasone pulses during maintenance treatment of childhood acute lymphoblastic leukemia on trial ALL-BFM 95. Leukemia 2017; 31: 1840-1842.
  • 3.
    Esteban F, Munoz M, Gonzalez-Moles M, Rosso M. A role for substance P in cancer promotion and progression: a mechanism to counteract intracellular death signals following oncogene activation or DNA damage. Cancer Metastasis Rev 2006; 25: 137-145.
  • 4.
    Munoz M, Rosso M, Coveas R. The NK-1 receptor is involved in the antitumoural action of L-733,060 and in the mitogenic action of substance P on human pancreatic cancer cell lines. Lett Drug Design Discov 2006; 3: 323-329.
  • 5.
    Akazawa T, Kwatra SG, Goldsmith LE, Richardson MD, Cox EA, Sampson JH, et al. A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptormediated apoptosis in glioblastomas. J Neurochem 2009; 109: 1079-1086.
  • 6.
    Munoz M, Rosso M, Prez A, Covenas R, Rosso R, Zamarriego C, et al. Antitumoral action of the neurokinin-1-receptor antagonist L-733,060 and mitogenic action of substance P on human retinoblastoma cell lines. Invest Ophthalmol Vis Sci 2005; 46: 2567-2570.
  • 7.
    Muoz M, Gonzlez-Ortega A, Coveas R. The NK-1 receptor is expressed in human leukemia and is involved in the antitumor action of aprepitant and other NK-1 receptor antagonists on acute lymphoblastic leukemia cell lines. Invest New Drugs 2012; 30: 529-540.
  • 8.
    Grassin-Delyle S, Buenestado A, Vallat L, Naline E, Marx S, Decocq J, et al. Expression and proliferative effect of hemokinin-1 in human B-cells. Peptides 2011; 32: 1027-1034.
  • 9.
    Quartara L, Altamura M, Evangelista S, Maggi CA. Tachykinin receptor antagonists in clinical trials. Expert Opin Investig Drugs 2009; 18: 1843-1864.
  • 10.
    Aapro M, Carides A, Rapoport BL, Schmoll H-J, Zhang L, Warr D. Aprepitant and fosaprepitant: a 10-year review of efficacy and safety. Oncologist 2015; 20: 450-458.
  • 11.
    Muoz M, Rosso M. The NK-1 receptor antagonist aprepitant as a broad spectrum antitumor drug. Invest New Drugs 2010; 28: 187-193.
  • 12.
    Muoz M, Gonzlez-Ortega A, Salinas-Martn MV, Carranza A, Garcia-Recio S, Almendro V, et al. The neurokinin-1 receptor antagonist aprepitant is a promising candidate for the treatment of breast cancer. Int J Oncol 2014; 45: 1658-1672.
  • 13.
    Nakade S, Ohno T, Kitagawa J, Hashimoto Y, Katayama M, Awata H, et al. Population pharmacokinetics of aprepitant and dexamethasone in the prevention of chemotherapy-induced nausea and vomiting. Cancer Chemother Pharmacol 2008; 63: 75-83.
  • 14.
    Kast RE, Ramiro S, Llad S, Toro S, Coveas R, Muoz M. Antitumor action of temozolomide, ritonavir and aprepitant against human glioma cells. J Neurooncol 2016; 126: 425-431.
  • 15.
    Garnier A, Ilmer M, Kappler R, Berger M. Therapeutic Innovations for Targeting Hepatoblastoma. Anticancer Res 2016; 36: 5577-5592.
  • 16.
    Garnier A, Vykoukal J, Hubertus J, Alt E, Von Schweinitz D, Kappler R, et al. Targeting the neurokinin-1 receptor inhibits growth of human colon cancer cells. Int J Oncol 2015; 47: 151-160.
  • 17.
    Muoz M, Coveas R. Neurokinin-1 receptor antagonists as antitumor drugs in gastrointestinal cancer: A new approach. Saudi J Gastroenterol 2016; 22: 260-268.
  • 18.
    Muoz M, Berger M, Rosso M, Gonzalez-Ortega A, Carranza A, Coveas R. Antitumor activity of neurokinin-1 receptor antagonists in MG-63 human osteosarcoma xenografts. Int J Oncol 2014; 44: 137-146.
  • 19.
    Bayati S, Bashash D, Ahmadian S, Safaroghli-Azar A, Alimoghaddam K, Ghavamzadeh A, et al. Inhibition of tachykinin NK 1 receptor using aprepitant induces apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells. Eur J Pharmacol 2016; 791: 274-283.
  • 20.
    Bayati S, Razani E, Bashash D, Safaroghli-Azar A, Safa M, Ghaffari SH. Antileukemic effects of neurokinin-1 receptor inhibition on hematologic malignant cells: a novel therapeutic potential for aprepitant. Anticancer Drugs 2018; 29: 243-252.
  • 21.
    Kryvenko ON, Williamson SR, Trpkov K, Gupta NS, Athanazio D, Selig MK, et al. Small cell-like glandular proliferation of prostate: a rare lesion not related to small cell prostate cancer. Virchows Arch 2017; 470: 47-54.

Similar Articles

30
Mar
2018

Induction of p21- and p27-mediated cell cycle arrest in Nalm-6 cells using pan-PI3K inhibitor (Buparlisib)

Ava Safaroghli-Azar,
Mohammadreza Sadri,
Davood Bashash

Safaroghli-Azar A, Sadri M, Bashash D. Induction of p21- and p27-mediated cell cycle arrest in Nalm-6 cells using pan-PI3K inhibitor (Buparlisib). koomesh. 2018;20(4):e153023. doi:

31
Dec
2019

Proteasome Inhibition by Carfilzomib Induced Apotosis and Autophagy in a T-cell Acute Lymphoblastic Leukemia Cell Line

Maryam Sadat Hosseini,
Mohammad Hossein Mohammadi,
Rouhollah Vahabpour Roudsari,
Leila Jafari,
Pargol Mashati,
Ahmad Gharehbaghian

Hosseini MS, Mohammadi MH, Vahabpour Roudsari R, Jafari L, Mashati P, et al. Proteasome Inhibition by Carfilzomib Induced Apotosis and Autophagy in a T-cell Acute Lymphoblastic Leukemia Cell Line. Iran J Pharm Res. 2019;18(Suppl1):e124462. doi: https://doi.org/10.22037/ijpr.2020.112692.13898

16
Feb
2021
Int J Cancer Manag

Inhibitor of Multi-cyclin-dependent Kinases (AT7519) Reduced Survival of U937 Leukemic Cells and Enhanced Anti-leukemic Effect of Vincristine: A Highlight to CDK Inhibition Efficacy in Acute Leukemia

Fateme Moradi Moraddahande,
Mona Shameli Houjghan,
Amir-Mohammad Yousefi,
Ava Safaroghli-Azar,
Atieh Pourbagheri-Sigaroodi,
Davood Bashash

Moradi Moraddahande F, Shameli Houjghan M, Yousefi A, Safaroghli-Azar A, Pourbagheri-Sigaroodi A, et al. Inhibitor of Multi-cyclin-dependent Kinases (AT7519) Reduced Survival of U937 Leukemic Cells and Enhanced Anti-leukemic Effect of Vincristine: A Highlight to CDK Inhibition Efficacy in Acute Leukemia. Int J Cancer Manag. 2021;14(2):e101366. doi: https://doi.org/10.5812/ijcm.101366

28
Sep
2016

Effects of all trans retinoic acid on apoptosis induction and notch1, hes1 genes expression in gastric cancer cell line MKN-45

nazila niapour,
samira shokri gara geshlagi,
mojtaba amani,
marzieh sharifi pasandi,
hossein salehi,
ali niapour

niapour N, shokri gara geshlagi S, amani M, sharifi pasandi M, salehi H, et al. Effects of all trans retinoic acid on apoptosis induction and notch1, hes1 genes expression in gastric cancer cell line MKN-45. koomesh. 2016;17(4):e151198. doi:

23
Apr
2019
87773

Myeloid Cell Leukemia-1 (MCL-1) siRNA Therapy Showed Cytotoxic Effect on T Cells Acute Lymphoblastic Leukemia

Shaghayegh Askarian-Amiri,
Farzane Ordoni Aval,
Abbas Azadmehr,
Morteza Oladnabi,
Mahjoobeh Jafari Vesiehsari,
Mahmoud Hajiahmadi

Askarian-Amiri S, Ordoni Aval F, Azadmehr A, Oladnabi M, Jafari Vesiehsari M, et al. Myeloid Cell Leukemia-1 (MCL-1) siRNA Therapy Showed Cytotoxic Effect on T Cells Acute Lymphoblastic Leukemia. Int J Cancer Manag. 2019;12(4):e87773. doi: https://doi.org/10.5812/ijcm.87773

Share on
Cited by
Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC 

Search Relations

Author(s):

Related Articles