Effects of Ziziphus jujube Mill., Cynara scolymus L. and and Cichorium intybus L. combination extract on non-alcoholic fatty liver disease in rats

Author(s):
Masumeh EslahiMasumeh Eslahi, Mojgan MohammadifarMojgan Mohammadifar, Mohsen TaghizadehMohsen Taghizadeh, Tahereh KhamechianTahereh Khamechian, Mahdi MehranMahdi Mehran, S. Alireza Talaei-ZavarehS. Alireza Talaei-Zavareh,*

Koomesh:Vol. 20, issue 4; 741-747
Published online:Mar 30, 2018
Article type:Research Article
Received:Sep 02, 2017
Accepted:Feb 03, 2018
How to Cite:Eslahi M, Mohammadifar M, Taghizadeh M, Khamechian T, Mehran M, et al. Effects of Ziziphus jujube Mill., Cynara scolymus L. and and Cichorium intybus L. combination extract on non-alcoholic fatty liver disease in rats. koomesh. 2018;20(4):e153021. doi:

Abstract

References

  • 1.
    Chan DF, Li AM, Chu WC, Chan MH, Wong EM, Liu EK. Hepatic steatosis in obese Chinese children. Int J Obes Relat Metab Disord 2004; 28: 1257-1263.
  • 2.
    Guijarro de Armas MG, Monereo MS, Navea AC, Merino VM, Vega Pinero MB. Non-alcoholic fatty liver in children and adolescents with excess weight and obesity. Med Clin (Barc) 2015; 144: 55-58.
  • 3.
    Kitade H, Chen G, Ni Y, Ota T. Nonalcoholic Fatty Liver Disease and Insulin Resistance: New Insights and Potential New Treatments. Nutrients 2017; 9: 387.
  • 4.
    Gungor N, Saad R, Janosky J, Arslanian S. Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents. J Pediatr 2004; 144: 47-55.
  • 5.
    Xanthakos S, Miles L, Bucuvalas J, Daniels S, Garcia V, Inge T. Histologic spectrum of nonalcoholic fatty liver disease in morbidly obese adolescents. Clin Gastroenterol Hepatol 2006; 4: 226-232.
  • 6.
    Vajro P, Lenta S, Socha P, Dhawan A, McKiernan P, Baumann U. Diagnosis of nonalcoholic fatty liver disease in children and adolescents: position paper of the ESPGHAN Hepatology committee. J Pediatr Gastroenterol Nutr 2012; 54: 700-713.
  • 7.
    Al-Reza SM, Yoon JI, Kim HJ, Kim JS, Kang SC. Anti-inflammatory activity of seed essential oil from Zizyphus jujuba. Food Chem Toxicol 2010; 48: 639-43.
  • 8.
    Cheng G, Bai Y, Zhao Y, Tao J, Liu Y, Tu G, et al. Flavonoids from Ziziphus jujuba Mill var. spinosa. Tetrahedron 2000; 56: 8915-8920.
  • 9.
    Shen X, Tang Y, Yang R, Yu L, Fang T, Duan Ja. The protective effect of Zizyphus jujube fruit on carbon tetrachloride-induced hepatic injury in mice by anti-oxidative activities. J Ethnopharmacology 2009; 122: 555-560.
  • 10.
    Zhao HX, Zhang HS, Yang SF. Phenolic compounds and its antioxidant activities in ethanolic extracts from seven cultivars of Chinese jujube. Food Sci Hum Well 2014; 3: 183-190.
  • 11.
    Lpez-Molina D, Navarro-Martnez MD, Rojas-Melgarejo F, Hiner AN, Chazarra S, Rodrguez-Lpez JN. Molecular properties and prebiotic effect of inulin obtained from artichoke (Cynara scolymus L.). Phytochemistry 2005; 66: 1476-1484.
  • 12.
    Rodriguez TS, Gimnez DG, De la Puerta Vzquez R. Choleretic activity and biliary elimination of lipids and bile acids induced by an artichoke leaf extract in rats. Phytomedicine 2002; 9: 687-693.
  • 13.
    Abd el Azeem E, Alaa B, Zakaria Z. Anti-obesity and anti-fatty liver effects of Cynara scolymus L. leaf extract in mice under diet-induced obesity. Int J Biochem Res Rev 2016; 11(1): 1-11.
  • 14.
    Zafar R, Ali SM. Anti-hepatotoxic effects of root and root callus extracts of Cichorium intybus L. J Ethnopharmacology 1998; 63: 227-231.
  • 15.
    Hassan HA, Yousef MI. Ameliorating effect of chicory (Cichorium intybus L.)-supplemented diet against nitrosamine precursors-induced liver injury and oxidative stress in male rats. Food Chem Toxicol 2010; 48: 2163-2169.
  • 16.
    El-Sayed YS, Lebda MA, Hassinin M, Neoman SA. Chicory (Cichorium intybus L.) root extract regulates the oxidative status and antioxidant gene transcripts in CCl 4-induced hepatotoxicity. PLoS One 2015; 10: e0121549.
  • 17.
    Emamat H, Noori M, Foroughi F, Rismanchi M, Eini-Zinab H, Hekmatdoost A. An accessible and pragmatic experimental model of nonalcoholic fatty liver disease. Middle East J Dig Dis 2016; 8: 109-115.
  • 18.
    Haghi G, Hatami A, Arshi R. Distribution of caffeic acid derivatives in Gundelia tournefortii L. Food Chem 2011; 124: 1029-1035.
  • 19.
    Abbas ZK, Saggu S, Sakeran MI, Zidan N, Rehman H, Ansari AA. Phytochemical, antioxidant and mineral composition of hydroalcoholic extract of chicory (Cichorium intybus L.) leaves. Saudi J Biol Sci 2015; 22: 322-326.
  • 20.
    Ahmed U, Redgrave TG, Oates PS. Effect of dietary fat to produce non-alcoholic fatty liver in the rat. J Gastroenterol Hepatol 2009; 24: 1463-1471.
  • 21.
    Kim HS. Effects of the Zizyphus jujuba seed extract on the lipid components in hyperlipidemic rats. J Food Sci Nutr 2002; 7: 72-77.
  • 22.
    Peng WH, Hsieh MT, Lee YS, Lin YC, Liao J. Anxiolytic effect of seed of Ziziphus jujuba in mouse models of anxiety. J Ethnopharmacol 2000; 72: 435-441.
  • 23.
    Yue Y, Wu S, Zhang H, Zhang X, Niu Y, Cao X, et al. Characterization and hepatoprotective effect of polysaccharides from Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou sarcocarp. Food Chem Toxicol 2014; 74: 76-84.
  • 24.
    Li JW, Fan LP, Ding SD, Ding XL. Nutritional composition of five cultivars of Chinese jujube. Food Chem 2007; 103: 454-460.
  • 25.
    Fritsche J, Beindorff CM, Dachtler M, Zhang H, Lammers JG. Isolation, characterization and determination of minor artichoke (Cynara scolymus L.) leaf extract compounds. Eur Food Res Technol 2002; 215: 149-157.
  • 26.
    Mocelin R, Marcon M, Santo GD, Zanatta L, Sachett A, Schnell AP, et al. Hypolipidemic and antiatherogenic effects of Cynara scolymus in cholesterol-fed rats. Revista Brasil Farmacogn 2016; 26: 233-239.
  • 27.
    Heidarian E, Rafieian-Kopaei M. Protective effect of artichoke (Cynara scolymus) leaf extract against lead toxicity in rat. Pharm Biol 2013; 51: 1104-1109.
  • 28.
    Rangboo V, Noroozi M, Zavoshy R, Rezadoost SA, Mohammadpoorasl A. The effect of artichoke leaf extract on alanine aminotransferase and aspartate aminotransferase in the patients with nonalcoholic steatohepatitis. Int J Hepatol 2016; 2016: 6.
  • 29.
    Asl ZS, Malekirad AA, Abdollahi M, Bakhshipour A, Dastjerdi HA, Mostafalou S, Poor RY. Effects of the mixture of cichorium intybus L. and Cinnamomum zeylanicum on hepatic enzymes activity and biochemical parameters in patients with nonalcoholic fatty liver disease. Health 2014; 6: 1212.

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