Effect of topotycan and zinc oxide nanoparticles combination on cytotoxicity and P53 gene expression against breast cancer (MCF-7) cell line

Author(s):
Alireza SharifianAlireza Sharifian, fahimeh baghbanifahimeh baghbani,*, Hasan SahebjamiHasan Sahebjami

Koomesh:Vol. 22, issue 1; 192-197
Published online:Mar 02, 2020
Article type:Research Article
Received:Mar 03, 2019
Accepted:Jul 02, 2019
How to Cite:Sharifian A, baghbani F, Sahebjami H. Effect of topotycan and zinc oxide nanoparticles combination on cytotoxicity and P53 gene expression against breast cancer (MCF-7) cell line. koomesh. 2020;22(1):e153167. doi:

Abstract

References

  • 1.
    DeSantis C, Ma J, Bryan L, Jemal A. Breast cancer statistics, 2013. CA Cancer J Clin 2014; 64: 52-62.
  • 2.
    Hollstein M, Sidransky D, Vogelstein B, Harris CC. P53 mutations in human cancers. Science 1991; 253: 49-53.
  • 3.
    Menendez JA, Lupu R. RNA interference-mediated silencing of the p53 tumor-suppressor protein drastically increases apoptosis after inhibition of endogenous fatty acid metabolism in breast cancer cells. Int J Mol Med 2005; 15: 33-40.
  • 4.
    Levine AJ. p53, the cellular gatekeeper for growth and division. Cell 1997; 88: 323-331.
  • 5.
    Lane DP, Lu X, Hupp T, Hall PA. The role of the p53 protein in the apoptotic response. Philos Trans R Soc Lond B Biol Sci 1994; 345: 277-280.
  • 6.
    Mashimo T, Watabe M, Hirota S, Hosobe S, Miura K, Tegtmeyer PJ, et al. The expression of the KAI1 gene, a tumor metastasis suppressor, is directly activated by p53. Proc Natl Acad Sci USA 1998; 95: 11307-11311.
  • 7.
    Zou Z, Gao C, Nagaich AK, Connell T, Saito S, Moul JW et al. p53 regulates the expression of the tumor suppressor gene maspin. J Biol Chem 2000; 275: 6051-6054.
  • 8.
    Hulla J, Sahu S, Hayes A. Nanotechnology: History and future. Hum Exp Toxicol 2015; 34: 1318-1321.
  • 9.
    Souza LG, Silva EJ, Martins AL, Mota MF, Braga RC, Lima EM, et al. Development of topotecan loaded lipid nanoparticles for chemical stabilization and prolonged release. Eur J Pharm Biopharm 2011; 79: 189-196.
  • 10.
    Shen B, Zhao K, Ma S, Yuan D, Bai Y. Topotecan-loaded mesoporous silica nanoparticles for reversing multi-drug resistance by synergetic chemoradiotherapy. Chem Asian J 2015; 10: 344-348.
  • 11.
    Nguyen D, Zajac-Kaye M, Rubinstein L, Voeller D, Tomaszewski JE, Kummar S, et al. Poly(ADP-ribose) polymerase inhibition enhances p53-dependent and independent DNA damageresponses induced by DNA damaging agent. Cell Cycle 2011; 10: 4074-4082.
  • 12.
    Patankar NA, Waterhouse D, Strutt D, Anantha M, Bally MB. topophore C: a liposomal nanoparticle formulation of topotecan for treatment of ovarian cancer. Invest New Drugs 2013; 31: 46-58.
  • 13.
    Mira K, Kwangsu O, Keunchang Ch, Sang-Woo J, So YL. Live-cell monitoring of the glutathione-triggered release of the anticancer drug topotecan on gold nanoparticles in serum-containing media. Chem Commun 2012; 48: 4205-4207.
  • 14.
    Rafieian-Kopaei M, Setorki M, Doudi M, Baradaran A, Nasri H. Atherosclerosis: process, indicators, risk factors and new hopes. Int J Prev Med 2014; 5: 927-946.
  • 15.
    Shandiz SA, Farasati S, Saeedi B, Baghbani-Arani F, Akbari Asl E, Keshavarz-Pakseresht B, et al. Up regulation of KAI1 gene expression and apoptosis effect of imatinib mesylate in gastric adenocarcinoma (AGS) cell line. Asian Pac J Trop Dis 2016; 6: 120-125.
  • 16.
    Santini D, Stumbo L, Spoto C, D'Onofrio L, Pantano F, Iuliani M, et al. Bisphosphonates as anticancer agents in early breast cancer: preclinical and clinical evidence. Breast Cancer Res 2015; 17: 121.
  • 17.
    Wahab R, Dwivedi S, Umar A, Singh S, Hwang IH, Shin HS, et al. ZnO nanoparticles induce oxidative stress in Cloudman S91 melanoma cancer cells. J Biomed Nanotechnol 2013; 9: 441-449.##.

Similar Articles

15
Aug
2022
Jentashapir J Cell Mol Biol

The Cytotoxic Effects of Zinc Oxide Nanoparticles on SW480 Cell Lines and Measurement of Nitric Oxide in Cell Culture Medium

Marjan Zargarnezhad,
Seyedeh Nasim Mirbahari,
Rahim Ahmadi

Zargarnezhad M, Mirbahari SN, Ahmadi R. The Cytotoxic Effects of Zinc Oxide Nanoparticles on SW480 Cell Lines and Measurement of Nitric Oxide in Cell Culture Medium. Jentashapir J Cell Mol Biol. 2022;13(1):e122530. doi: https://doi.org/10.5812/jjcmb-122530

16
Sep
2018
https://www.shiftfrequency.com/michael-edwards-candida-albicans-the-foundation-of-illness/

Novel Formulated Zinc Oxide Nanoparticles Reduce Hwp1 Gene Expression Involved in Biofilm Formation in Candida albicans with Minimum Cytotoxicity Effect on Human Cells

Peyman Aslani,
Shahla Roudbar Mohammadi,
Maryam Roudbary

Aslani P, Roudbar Mohammadi S, Roudbary M. Novel Formulated Zinc Oxide Nanoparticles Reduce Hwp1 Gene Expression Involved in Biofilm Formation in Candida albicans with Minimum Cytotoxicity Effect on Human Cells. Jundishapur J Microbiol. 2018;11(10):e79562. doi: https://doi.org/10.5812/jjm.79562

17
Dec
2021

Tin (IV) Oxide (SnO2 ) Nanoparticles Inhibit the Viability of Cervical Cancer HeLa Cells Through Induction of Apoptosis

Parisa bazsefidpar,
Shabnaz Koochakkhani,
Behnaz Rahnama inchehsablagh,
Ebrahim Eftekhar,
Elahe Aliasgari

bazsefidpar P, Koochakkhani S, Rahnama inchehsablagh B, Eftekhar E, Aliasgari E. Tin (IV) Oxide (SnO2 ) Nanoparticles Inhibit the Viability of Cervical Cancer HeLa Cells Through Induction of Apoptosis. J Rep Pharm Sci. 2021;10(2):e146886. doi: https://doi.org/10.4103/jrptps.JRPTPS_109_20

1
Aug
2023

Evaluation of Cytotoxic and Apoptotic Effects of Green Synthesized Zn Oxide Nanoparticles on the MCF-7 breast cancer Cell Line

Parisa Shishesaz,
Masoumeh Mahdavi,
Fatemeh Ghodratpour,
fahimeh baghbani-arani

Shishesaz P, Mahdavi M, Ghodratpour F, baghbani-arani F. Evaluation of Cytotoxic and Apoptotic Effects of Green Synthesized Zn Oxide Nanoparticles on the MCF-7 breast cancer Cell Line. koomesh. 2023;25(2):e152825. doi:

31
Jul
2018

Molecular and Biochemical Evidences for Beneficial Effects of Zinc Oxide Nanoparticles in Modulation of Chlorpyrifos Toxicity in Human Lymphocytes

Mona Navaei-Nigjeh,
Mahdi Gholami,
Maryam Sadat Fakhri-Bafghi,
Maryam Baeeri,
Mohammad Abdollahi

Navaei-Nigjeh M, Gholami M, Fakhri-Bafghi MS, Baeeri M, Abdollahi M. Molecular and Biochemical Evidences for Beneficial Effects of Zinc Oxide Nanoparticles in Modulation of Chlorpyrifos Toxicity in Human Lymphocytes. Iran J Pharm Res. 2018;17(3):e124780. doi: https://doi.org/10.22037/ijpr.2018.2261

Share on
Cited by
Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC 

Search Relations

Author(s):

Related Articles