Journal of Semnan University of Medical Sciences
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Outline
Comparing the effect of metoclopramide and promethazine on preventing nausea and vomiting after laparoscopic cholecystectomy: A double-blind clinical trial
Authors
Abstract
Introduction: Nausea and vomiting are conditions that could occur after anesthesia and lead to reduced activity and surgery dissatisfaction. Therefore, according to its importance, this study was accomplished in order to compere the effect of metoclopramide and promethazine on preventing nausea and vomiting after laparoscopic cholecystectomy. Materials and Methods: This study was a double-blind clinical trial of 60 ASA class I and II patients aged 18-70 who visited for elective laparoscopic cholecystectomy surgery. Patients were randomly divided into two groups, namely metoclopramide 10mg and promethazine 1mg/kg. The occurrence and intensity of nausea and vomiting, the hemodynamic parameters of patients before induction and one minute, 5 minutes, and 15 minutes after induction, and recovery at moment zero and after 30 minutes, one hour, and 2 hours were measured and recorded. Results: Hemodynamic parameters including heart rate (HR) and mean arterial pressure (MAP) were compared for the two groups in different times. Although no significant difference was observed in MAP analysis before recovery, the difference between the two groups during recovery was statistically significant (P>0.05). In HR analysis, the difference between different times was not statistically significant (P
References
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Copyright
© 2021, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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