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Background:
Post-operative nausea and vomiting (PONV) is one of the common problems after laparoscopic cholecystectomy.
e-ISSN 2228-7531
p-ISSN 2228-7523
Granisetron Versus Dexamethasone in Prophylaxis of Nausea and Vomiting After Laparoscopic Cholecystectomy
Authors
1Department of Surgery, Kermanshah University of Medical Sciences, IR Iran
2Clinical Research Development Center, Imam Reza Hospital, Department of Anesthesiology, Kermanshah University of Medical Sciences, myari@kums.ac.ir, IR Iran
*Corresponding Author: Department of Anesthesiology, Kermanshah University of Medical Sciences, Imam Reza Hospital, Parastar Blvd., myari@kums.ac.ir, IR Iran. Tel: +98-9181314380. Fax: +98-8314276310. Email: myari@kums.ac.ir
Published online:Sep 26, 2012
Article type:Research Article
Received:Jun 27, 2012
Accepted:Jul 26, 2012
How to Cite:Hessami MA, Yari M. Granisetron Versus Dexamethasone in Prophylaxis of Nausea and Vomiting After Laparoscopic Cholecystectomy. Anesth Pain Med. 2012;2(2):. doi: https://doi.org/10.5812/aapm.6945
Abstract
Objectives:
The current study aimed to compare Dexamethasone effect with that of Granisetron in prevention of PONV.
Patients and Methods:
In the current study 104 patients aged 20-60 with ASA class I or II who were candidates for laparoscopic cholecystectomy were included in the study. Patients were randomly divided into two groups of A and B. 15 minutes before anesthesia induction, in group a patients 3 mg Granisetron and in group B patients 8 mg Dexamethasone was intravenously injected. Then both groups underwent general anesthesia with similar medications. After operation the prevalence of nausea and vomiting was assessed at three time intervals (0-6 hours, 6-12 hours and 12-24 hours after consciousness). SPSS software version 16 was employed to analyze data. T test, chi-square test and Fischer exact test were performed level of significance was
Results:
There was no significant difference between age, gender proportion, weight, height, and body mass index (BMI) of patients in the two groups. In Dexamethasone group, seven patients experienced nausea and three patients had vomiting, and in Granisetron group, five patients experienced nausea and three patients had vomiting after consciousness. Statistical analysis indicated no significant difference between the two groups in this regard.
Conclusions:
Intravenous injection of 8 mg Dexamethasone or 3 mg Granisetron before anesthesia induction had similar effects in prophylaxis of nausea and vomiting after laparoscopic cholecystectomy.
Highlights
Copyright
© 2012, Author(s). The Author(s) retain copyright in the Article. Upon acceptance, the Author(s) grant Brieflands the non-exclusive right of first publication and a worldwide, perpetual, royalty-free, non-exclusive license to copyedit, format, publish, reproduce, distribute, display, preserve, archive, index, promote, and make the Version of Record available in all formats and media. Brieflands and the relevant journal will be identified as the original publisher of the Version of Record. The Article will be published under the [Creative Commons Attribution 4.0 International License (CC BY 4.0)](https://creativecommons.org/licenses/by/4.0/). The Author(s) may immediately deposit and share the Version of Record in any repository or platform. No separate permission or fee is required for uses permitted under CC BY 4.0. CCC may provide optional customized reprint services.
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