Hyperglycemia After Renal Transplantation: Frequency and Risk Factors

Khalili, Nahid; Rostami, Zohreh; Kalantar, Ebrahim; Einollahi, Behzad

doi:10.5812/numonthly.10773

Cover image of the article: Hyperglycemia After Renal Transplantation: Frequency and Risk Factors

Image Credit:Nephro-Urol Mon

Outline

Abstract
Copyright

https://doi.org/10.5812/numonthly.10773

Hyperglycemia After Renal Transplantation: Frequency and Risk Factors

Authors

Nahid Khalili¹, Zohreh Rostami^1,*, Ebrahim Kalantar², Behzad Einollahi¹

Abstract

Background:

Chronic renal failure is an important and common complication of diabetes mellitus; hence, renal transplantation is a frequent and the acceptable treatment in patients with diabetic nephropathy requiring renal replacement therapy. On the other hand, renal transplantation and its conventional treatment can lead to increased diabetes outbreak in normoglycemic recipients. Also, uncontrolled hyperglycemia may be increased and allograft lost thus decreasing patient survival.

Objectives:

We aimed to assess the frequency of hyperglycemia in transplant patients and its risk factors.

Patients and Methods:

A large retrospective study was performed on 3342 adult kidney transplant recipients between 2008 and 2010. Demographic and laboratory data were gathered for each patient. All tests were done in a single laboratory and hyperglycemia was defined as a fasting plasma glucose of > 125 mg/dL. Univariate and multivariate logistic regression analyses were used to determine the risk factors of hyperglycemia following kidney transplantation.

Results:

There were 2120 (63.4%) males and 1212 (36.3%) females. Prevalence of hyperglycemia was 22.5%. By univariate linear regression, hyperglycemia was significantly higher in patients with CMV infection (P = 0.001), elevated serum creatinine (P = 0.000), low HDL (P = 0.01), and increased blood levels of cyclosporine (P = 0.000). After adjusting for covariates by multivariate logistic regression, the hyperglycemia rate was significantly higher for patients with Cyclosporine trough level > 250 (P = 0.000), serum creatinine > 1.5 (P = 0.000) and HDL < 45 (P = 0.03).

Conclusions:

This study indicated that hyperglycemia is a common metabolic disorder in Iranian kidney transplant patients. Risk factors for hyperglycemia were higher Cyclosporine level, impaired renal function, and reduced HDL value.

Highlights

KeywordsKidney Transplantation Hyperglycemia Diabetes Mellitus

How to Cite:Khalili N, Rostami Z, Kalantar E, Einollahi B. Hyperglycemia After Renal Transplantation: Frequency and Risk Factors. Nephro-Urol Mon. 2013;5(2):. doi: https://doi.org/10.5812/numonthly.10773

Full Text

Full text is available in PDF

Copyright

© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.

Similar Articles

Jun

2026

Pre-diabetes and Diabetes in Heart Transplant Recipients: Epidemiological Insights from a Decade-Long Study

Sanaz Soleimani,

Fatemeh Kazemi Hasnijeh,

Maryam Vasheghani,

Farah Naghashzadeh,

Zargham Hossein Ahmadi,

Babak Sharif Kashani

,et al.

PDF

Soleimani S, Kazemi Hasnijeh F, Vasheghani M, Naghashzadeh F, Ahmadi ZH, et al. Pre-diabetes and Diabetes in Heart Transplant Recipients: Epidemiological Insights from a Decade-Long Study. Int J Endocrinol Metab. 2026;24(4):e168325. doi: https://doi.org/10.5812/ijem-168325

Jan

2020

Association Between Pre-Transplant Magnesemia and Post-Transplant Dysglycemia in Kidney Transplant Recipients

Azam Alamdari,

Ghazal Asadi,

Farzaneh Sadat Minoo,

Mohammad-Reza Khatami,

Seyed Mansour Gatmiri,

Simin Dashti-Khavidaki

,et al.

PDF

Alamdari A, Asadi G, Minoo FS, Khatami M, Gatmiri SM, et al. Association Between Pre-Transplant Magnesemia and Post-Transplant Dysglycemia in Kidney Transplant Recipients. Int J Endocrinol Metab. 2020;18(1):e97292. doi: https://doi.org/10.5812/ijem.97292

Apr

2017

Side Effects of Transplant Immunosuppressive Therapy in Post Renal Transplant Recipients, Mazandaran, Northern Iran

Abazar Akbarzadeh Pasha,

Shayan Alijanpour,

Soraya Khafri,

Hoshmand Basim,

Mehran Afshang

PDF

Akbarzadeh Pasha A, Alijanpour S, Khafri S, Basim H, Afshang M. Side Effects of Transplant Immunosuppressive Therapy in Post Renal Transplant Recipients, Mazandaran, Northern Iran. Zahedan J Res Med Sci. 2017;19(4):e6560. doi: https://doi.org/10.5812/zjrms.6560

Jun

2013

Dyslipidemia After Kidney Transplantation and Correlation With Cyclosporine Level

Mahboobeh-Sadat Hosseini,

Zohreh Rostami,

Behzad Einollahi

PDF

Hosseini M, Rostami Z, Einollahi B. Dyslipidemia After Kidney Transplantation and Correlation With Cyclosporine Level. Nephro-Urol Mon. 2013;5(3):. doi: https://doi.org/10.5812/numonthly.11890

Jan

2013

Prevalence of Overweight and Obesity in Kidney Transplant Patients

Sahar Keshtkar-Aghababaee,

Vida Mohammadi

PDF

Keshtkar-Aghababaee S, Mohammadi V. Prevalence of Overweight and Obesity in Kidney Transplant Patients. Zahedan J Res Med Sci. 2014;16(8):. doi:

More by these authors

Nahid KhaliliPubMed Scholar

Zohreh RostamiPubMed Scholar

Ebrahim KalantarPubMed Scholar

Behzad EinollahiPubMed Scholar

Find related work

PubMed

Google Scholar

Create citation alert

Download PDF497.02 KB

Cited by

Scopus by DOI: 8
Last Update: 1 month ago
Scopus by Title: 8
Last Update: 1 month ago
Scopus by Title (Ref): 8
Last Update: 1 month ago
CrossRef: 5
Last Update: 4 days ago
OpenAlex: 10
Last Update: 2 days ago
OpenCitations: 8
Last Update: 2 days ago

Metrics

Comments

Number of Comments:0

Indexed in

ISC