Shiraz E-Medical Journal
Patients with rheumatoid arthritis (RA) are at increased risk of developing low bone mineral density. The aim of the present study was to compare the bone mineral density of Iranian female RA patients with healthy controls.
In this case-control study, bone mineral density of 391 rheumatoid arthritis patients and 391 healthy controls referred during a 4-year period (2003-2007) to Imam Khomeini Hospital in Tehran, were studied. Patients were assigned in two subgroups; group 1 (n=184) with a history of current oral corticosteroid use and group 2 (n=207) with-out corticosteroid use. Dual-energy x-ray absorptiometry technique was used to measure bone density. Differences between groups were analyzed using Fisher's exact test. Duncan test and Schaffer test were used to compare mean difference between each two groups.
Among ?45 and >60 years females, bone density did not show a significant differ-ence at lumbar region between the 3 groups, however, the differences at femoral neck were statistically significant (p<0.04 for ?45 years and p<0.0003 for >60 years). Among subjects aged 46-60 years, bone mineral density showed significant differences at both lumbar and femoral neck regions (p<0.001, p<0.001, respectively).
Low bone density in Iranian female patients with RA is in accordance with west-ern societies. Among RA female patients the risk of BMD reduction is increased by age and partly by oral glucocorticoids. Therefore, routine BMD evaluation is strongly suggested for RA patients.
© 2010, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Shirani F, Shahbazian AM, Razi S. Comparing Bone Mineral Density in Rheumatoid Arthritis and Psoriatic Arthritis. J Inflamm Dis. 2024;25(2):e156278. doi:
Pajoohi M, Hossein-nezhad A, Soltani A, Maghbooli J, Madani F, et al. Bone mineral density variations in 10-75 years-old women inhabitants of Tehran. Zahedan J Res Med Sci. 2003;5(1):e95135. doi:
Shams M, Homayouni K, Hamidi A, Sadegholvad A, Omrani G. Leptin and Bone Mineral Density in Healthy Postmenopausal Iranian Women: A Population-based Study. Int J Endocrinol Metab. 2006;4(2):. doi:
Bekheirnia M, Pajoohi M, Baradar Jalili R, Erfanzadeh G, Larijani B. Bone Mineral Density In Male population: Association With Dietary Calcium Intake And Blood reassure. Zahedan J Res Med Sci. 2003;5(2):e95152. doi:
Bordbar M, Olyaeinezhad S, Saki F, Haghpanah S. Prevalence of Low Bone Mass in Patients with Hemophilia and Its Related Ractors in Southern Iran. J Compr Ped. 2020;11(4):e97291. doi: https://doi.org/10.5812/compreped.97291
Ordering Reprints
Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCCÂ
