Intracellular Neutrophil Myeloperoxidas in Myocardial Infarction

Abstract:

A growing body of evidence suggests that inflammation may play a role in unstable angina and acute myocardial infarction. Neutrophil activation has been demonstrated in unstable angina and acute myocardial infarction. Myeloperoxidase is the major constituent of primary azurophil granules is neutrophil and discharged after activation. The chart of thirty-two patients (female 19 male 13) who were admitted in coronary care unit because of myocardial infarction and unstable angina pectoris were selected. Myeloperoxidase content (MPxI) had been determined using H1 hematology analyzer. In normal subjects this index is about 0 and negative values appear when the neutrophil are depleted of myeloperoxidase, which typically happens after neutrophil activation. Risk factors such as current smoking, hypertension, diabetes mellitus and high cholesterol level were recorded. The mean age of patients was 65 years old (female 66 male 64) with a range of 29 to 91. Leukocytosis and neutrophilia were present in 13 (40%) and 16 (50%) respectively. The range of ESR was between 1 to 28 (millimeter/hours) with mean = 10.4. The mean of MPxI was -3.04 (female -4.5 male -1.3, P = 0.27). MPxI in patients who had positive and negative history of chronic stable angina was -5.14 and -2.3 (P = 0.64) respectively. Because most of the patients had two or more risk factors, the relation between risk factors and MPxI, independently, was not possible to evaluate. There was no correlation between amount of creatin phosphokinase rising and age with MPxI values. During myocardial ischemia, neutrophil activity is increased. Further study is needed for determination whether neutrophil activation is caused by myocardial event or whether it is an independent, primary event.