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Zahedan Journal of Research in Medical Sciences
The Official Journal of Zahedan University of Medical Sciences
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Protective Effects of Captopril against Aflatoxin B1-Induced Hepatotoxicity in Isolated Perfused Rat Liver
Author(s):
1Tehran, Department of Toxicology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
2Department of Toxicology, Faculty of VeterinarMedicine, University of Tehran, Tehran, Iran
3Department of Pharmacology, Tehran University of Medical Sciences, Tehran, Ira, Tehran, Iran
4Department of Medical Biochemistry, Tehran Universit y of Medical Sciences , Tehran, Iran
*Corresponding Author: Tehran, Department of Toxicology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran Email: [email protected]
Published online:Jan 21, 2013
Article type:Research Article
Received:Sep 23, 2012
Accepted:Oct 30, 2012
How to Cite:Moghaddam-Jafari A, Kazem Koohi M, Ghazi Khansari M, Pasalar P. Protective Effects of Captopril against Aflatoxin B1-Induced Hepatotoxicity in Isolated Perfused Rat Liver. Zahedan J Res Med Sci. 2014;16(2):. doi:
Abstract
Background: The liver is the major target organ for aflatoxin B1 (AFB1). Ingestion of aflatoxin causes hepatotoxicty. In this study, captopril as new agent to help the hepatotoxicity induced by aflatoxin was suggested.
Materials and Methods: The isolated perfused rat liver (IPRL) was chosen for evaluating hepatic function. Sixteen rats were divided randomly into four experimental groups: control, captopril, AFB1 and AFB1 + captopril. The level of glutathione content and lipid peroxidation, as marker of oxidative stress and lactate dehydrogenase (LDH), alanine transaminase (ALT) and aspartate transaminase (AST) activities and pH of the perfusate medium were measured.
Results: There was a significant decrease in lipid peroxidation and same increase was observed in glutathione level. Treatment with captopril also modulated the enzymes activity and pH of perfusate.
Conclusion: This study showed that captopril protects the hepatotoxicty induced by AFB1. Therefore, this drug may provide an effective new strategy to reduce of aflatoxins toxicity.
References
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Copyright
© 2014, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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