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Zahedan Journal of Research in Medical Sciences
The Official Journal of Zahedan University of Medical Sciences
e-ISSN 2383-2894
Image Credit:Zahedan J Res Med Sci
Outline
Salvia Officinalis and Cisplatin Effects on Pentylenetetrazole Induced Seizure Threshold
Authors
1Department of Pharmacology and Toxicology, Tabriz Branch, Islamic Azad University, Tabriz, Iran
2Young Researchers Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran
*Corresponding Author: Young Researchers Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran Email: ali.namvaran@gmail.com
Published online:Nov 11, 2013
Article type:Research Article
Received:Jun 18, 2012
Accepted:Sep 25, 2012
How to Cite:Khayate-Nouri MH, Namvaran-Abbasabad A, Tavakkoli F. Salvia Officinalis and Cisplatin Effects on Pentylenetetrazole Induced Seizure Threshold. Zahedan J Res Med Sci. 2013;15(11):e92773. doi:
Abstract
Background: Studies have shown that cisplatin have neuropathic effects and Salvia officinalis (SO) could have therapeutic effects on nervous system. The aim of this study was to investigate the effects of SO hydroalcoholic extract and cisplatin on pentylenetetrazole (PTZ) induced seizure in mice.
Materials and methods: This is an experimental interventional study. For this purpose first group received normal saline, second group received SO extract, third group received cisplatin, in the fourth group received SO extract plus cisplatin and the subsequent seizure threshold was determined for each group.
Results: The results showed that SO extract significantly (p<0.05) increased and in cisplatin group significantly (p<0.05) decreased seizure threshold. Simultaneous uses of cisplatin and SO extract caused to significantly increased seizure threshold (p<0.05) compared with cisplatin group.
Conclusion: Considering different types of ingredients in SO extract which have beneficial effects on nervous system, it might be used to reduce cisplatin induced neuropathic effects. It seems that SO extract could be useful in cisplatin-induced seizure but further investigations are needed.
Highlights
References
- 1.The References of this article are available on the PDF file.
Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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