Effects of Salvia Sahendica hydroalcoholic extract on PTZ-induced seizure in male mice

 Introduction: Epilepsy is one of most prevalent disorders of central nervous system that causes sudden convulsions, transient, repetitive and unpredictable seizures. It affects about half to one percent of the world population. Historically, herbs have been used to treat epilepsy. In this study, anti-convulsant effect of Salvia Sahendica extract was investigated in mice.  Materials and Methods: Sixty mice were randomly divided into six groups (n=10 in each group). Group one (control group) was received normal saline and another 5 groups were received 150, 300, 600, 900, 1200 mg/kg of the extract. Thirty minute after peritoneal injection of different doses of extract or saline, PTZ (85 mg/kg) were injected and they were immediately transferred to a special cage, and the seizure parameters were evaluated for 30 minutes. Results: The injection of the extract had a dose-dependent effect on prolongation of latency to the onset of clonic and tonic-clonic seizures. The greatest effect was observed at the dose of 600 mg/kg. Tonic-clonic seizures time in the treated animals was also reduced. Additionally, it decreased the rate of mortality and the number of suddenly seizures jumping significantly.  Conclusion: The obtained result showed that the extract of Salvia Sahendica has anticonvulsant effects. However, more studies are required to understand its action mechanism and to identify the active components.