Effect of Biebersteinia Multifida DC. Root Extract on Cholesterol in Mice

shahrzad khakpour; Meisam Akhlaghdoust; Sara Naimi; S. Mohammad-Javad Mirlohi; Media Abedian; Nazilla Sadat Seyed-Forootan; Fatemeh Foroughi

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

Current Issue All Issues In Press Articles Accepted Manuscripts Search

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Reviewer and AE Registration Form Support Contact Us

APC

Authors Guide Submit Manuscript

Effect of Biebersteinia Multifida DC. Root Extract on Cholesterol in Mice

Author(s):

shahrzad khakpour^1,*,

Meisam Akhlaghdoust²,

Sara Naimi²,

S. Mohammad-Javad Mirlohi²,

Media Abedian²,

Nazilla Sadat Seyed-Forootan²,

Fatemeh Foroughi²

1Department of Physiology, Medical Sciences Research Center, Islamic Azad University, Tehran Medical Branch, Tehran, Iran

2Medical Students Research Committee, Islamic Azad University, Tehran Medical Branch, Tehran, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 15, issue 11; e92804

Published online:Feb 02, 2013

Article type:Research Article

Received:Oct 09, 2012

Accepted:Jan 23, 2013

How to Cite:khakpour S, Akhlaghdoust M, Naimi S, Mirlohi SM, Abedian M, et al. Effect of Biebersteinia Multifida DC. Root Extract on Cholesterol in Mice. Zahedan J Res Med Sci. 2013;15(11):e92804. doi:

Abstract

Background : Hypercholesterolemia and atherosclerosis are the most common causes of mortality and disability, especially in developed countries. The aim of this research was to evaluate the effect of Biebersteina multifida DC. root extract on HDL and LDL blood level.
Materials and Methods : In this experimental study, 35 male Balb/c mice were randomly divided in five groups such control, sham, and experimental groups which received Biebersteina multifida DC. root extract with the doses of 4, 5 and 10 mg/kg three last groups were daily fed orally, for thirty days. HDL and LDL blood serum levels were measured, in the last day and compared with control and sham groups.
Results : The results after 30 days gavage of 4, 5 and 10 mg/kg of Biebersteinia Multifida DC. root extract showed that the root extract decrease of LDL level significantly. The doses of 4, 5 mg/kg of the root extract were the effective dose in decreasing the serum HDL level. However, 10 mg/kg dose of root extract has no significant effect on HDL level in comparison with control and sham groups. 10 mg/kg of root extract had the maximum effect on reducing LDL level.
Conclusion : According to this study, it is suggested that the root extract of Biebersteinia multifida DC. can be efficient to reduce the level of HDL and LDL in blood serum.

Keywords

Bibersteinia multifida DC.

HDL

LDL

Mice

Fulltext

The full text of this article is available on the PDF file.

References

1.
The References of this article are available on the PDF file.

Combined Administration of Melissa officinalis and Boswellia serrata Extracts in an Animal Model of Memory

Mohaddese Mahboubi,

Mohsen Taghizadeh,

Sayyed Alireza Talaei,

Sayyed Mehdi Takht Firozeh,

Ali Akbar Rashidi,

Omid Reza Tamtaji

Mahboubi M, Taghizadeh M, Talaei SA, Takht Firozeh SM, Rashidi AA, et al. Combined Administration of Melissa officinalis and Boswellia serrata Extracts in an Animal Model of Memory. Iran J Psychiatry Behav Sci. 2016;10(3):e681. doi: https://doi.org/10.17795/ijpbs-681

14

Dec

2025

Short-term Antihyperglycemic and Weight Modulation Effects of Leuenbergeria bleo (Kunth) Lodé: Phytochemical Screening and in vivo Assessment in an Alloxan-Induced Diabetic Rat Model

Sheryar Afzal,

Velaga Venkata Sathya Sai Appalaraju,

Ali Attiq,

Iram Malik,

Ibrahim Albokhadaim,

Sameer M Alhojaily

,et al.

Afzal S, Venkata Sathya Sai Appalaraju V, Attiq A, Malik I, Albokhadaim I, et al. Short-term Antihyperglycemic and Weight Modulation Effects of Leuenbergeria bleo (Kunth) Lodé: Phytochemical Screening and in vivo Assessment in an Alloxan-Induced Diabetic Rat Model. Iran J Pharm Res. 2025;24(1):e164873. doi: https://doi.org/10.5812/ijpr-164873

31

Oct

2014

Effect of Dietary Ethanolic Extract of Lavandula officinalis on Serum Lipids Profile in Rats

Zahra Rabiei,

Mahmoud Rafieian-Kopaei,

Shiva Mokhtari,

Mehrdad Shahrani

Rabiei Z, Rafieian-Kopaei M, Mokhtari S, Shahrani M. Effect of Dietary Ethanolic Extract of Lavandula officinalis on Serum Lipids Profile in Rats. Iran J Pharm Res. 2014;13(4):e125563. doi: https://doi.org/10.22037/ijpr.2014.1586

20

Nov

2010

Badrakemonin, a New Eremophilane-Type Sesquiterpenefrom the Roots of Ferula badrakema Kos.-Pol.

Mehrdad Iranshahi,

Maral Ghiadi,

Amirhossein Sahebkar,

Atena Rahimi,

Carla Bassarello,

Sonia Piacente

,et al.

Iranshahi M, Ghiadi M, Sahebkar A, Rahimi A, Bassarello C, et al. Badrakemonin, a New Eremophilane-Type Sesquiterpenefrom the Roots of Ferula badrakema Kos.-Pol.. Iran J Pharm Res. 2022;8(4):e128649. doi: https://doi.org/10.22037/ijpr.2010.822

7

Oct

2012

The Antioxidant Capacity and Anti-diabetic Effect of Boswellia serrata Triana and Planch Aqueous Extract in Fertile Female Diabetic Rats and the Possible Effects on Reproduction and Histological Changes in the Liver and Kidneys

Mohamad Ebrahim Azemi,

Foroogh Namjoyan,

Mohammad Javad Khodayar,

Forouzan Ahmadpour,

Azam Darvish Padok,

Marziyeh Panahi

Azemi ME, Namjoyan F, Khodayar MJ, Ahmadpour F, Darvish Padok A, et al. The Antioxidant Capacity and Anti-diabetic Effect of Boswellia serrata Triana and Planch Aqueous Extract in Fertile Female Diabetic Rats and the Possible Effects on Reproduction and Histological Changes in the Liver and Kidneys. Jundishapur J Nat Pharm Prod. 2012;7(4):168-175. doi: https://doi.org/10.17795/jjnpp-6755

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 2 days ago
Scopus by Title: 0
Last Update: 2 days ago
Scopus by Title (Ref): 6
Last Update: 2 days ago
CrossRef: 0
Last Update: 4 days ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

shahrzad khakpour:[PubMed][Scholar]
Meisam Akhlaghdoust:[PubMed][Scholar]
Sara Naimi:[PubMed][Scholar]
S. Mohammad-Javad Mirlohi:[PubMed][Scholar]
Media Abedian:[PubMed][Scholar]
Nazilla Sadat Seyed-Forootan:[PubMed][Scholar]
Fatemeh Foroughi:[PubMed][Scholar]

The Official Journal of Zahedan University of Medical Sciences

Outlines

Effect of Biebersteinia Multifida DC. Root Extract on Cholesterol in Mice

Abstract

Fulltext

References

Similar Articles

Combined Administration of Melissa officinalis and Boswellia serrata Extracts in an Animal Model of Memory

Short-term Antihyperglycemic and Weight Modulation Effects of Leuenbergeria bleo (Kunth) Lodé: Phytochemical Screening and in vivo Assessment in an Alloxan-Induced Diabetic Rat Model

Effect of Dietary Ethanolic Extract of Lavandula officinalis on Serum Lipids Profile in Rats

Badrakemonin, a New Eremophilane-Type Sesquiterpenefrom the Roots of Ferula badrakema Kos.-Pol.

The Antioxidant Capacity and Anti-diabetic Effect of Boswellia serrata Triana and Planch Aqueous Extract in Fertile Female Diabetic Rats and the Possible Effects on Reproduction and Histological Changes in the Liver and Kidneys

Last Update: 2 days ago

Last Update: 2 days ago

Last Update: 2 days ago

Last Update: 4 days ago