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Zahedan Journal of Research in Medical Sciences
The Official Journal of Zahedan University of Medical Sciences
e-ISSN 2383-2894
Image Credit:Zahedan J Res Med Sci
Outline
Effect of Biebersteinia Multifida DC. Root Extract on Cholesterol in Mice
Authors
shahrzad khakpour1,*, Meisam Akhlaghdoust2, Sara Naimi2, S. Mohammad-Javad Mirlohi2, Media Abedian2, Nazilla Sadat Seyed-Forootan2, Fatemeh Foroughi2
1Department of Physiology, Medical Sciences Research Center, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
2Medical Students Research Committee, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
*Corresponding Author: Department of Physiology, Medical Sciences Research Center, Islamic Azad University, Tehran Medical Branch, Tehran, Iran Email: shahrzad_khakpour@yahoo.com
Published online:Feb 02, 2013
Article type:Research Article
Received:Oct 09, 2012
Accepted:Jan 23, 2013
How to Cite:khakpour S, Akhlaghdoust M, Naimi S, Mirlohi SM, Abedian M, et al. Effect of Biebersteinia Multifida DC. Root Extract on Cholesterol in Mice. Zahedan J Res Med Sci. 2013;15(11):e92804. doi:
Abstract
Background : Hypercholesterolemia and atherosclerosis are the most common causes of mortality and disability, especially in developed countries. The aim of this research was to evaluate the effect of Biebersteina multifida DC. root extract on HDL and LDL blood level.
Materials and Methods : In this experimental study, 35 male Balb/c mice were randomly divided in five groups such control, sham, and experimental groups which received Biebersteina multifida DC. root extract with the doses of 4, 5 and 10 mg/kg three last groups were daily fed orally, for thirty days. HDL and LDL blood serum levels were measured, in the last day and compared with control and sham groups.
Results : The results after 30 days gavage of 4, 5 and 10 mg/kg of Biebersteinia Multifida DC. root extract showed that the root extract decrease of LDL level significantly. The doses of 4, 5 mg/kg of the root extract were the effective dose in decreasing the serum HDL level. However, 10 mg/kg dose of root extract has no significant effect on HDL level in comparison with control and sham groups. 10 mg/kg of root extract had the maximum effect on reducing LDL level.
Conclusion : According to this study, it is suggested that the root extract of Biebersteinia multifida DC. can be efficient to reduce the level of HDL and LDL in blood serum.
Highlights
References
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Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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