Effect of Memory Attenuation on Creating Morphine Dependency in Male Mature Mice

How to Cite:Hosseini SE. Effect of Memory Attenuation on Creating Morphine Dependency in Male Mature Mice. Zahedan J Res Med Sci. 2013;15(10):e92833. doi:

Abstract

Background : Morphine and other addicting drugs induce an uncontrolled desire in man to consume the drugs overtly and stimulate the brain compensative systems such that the neuron sensitivity produced is not desensitized for some time after the consumption and detoxification of the drug. Therefore, the aim of this study is to examine the effect of memory attenuation in creating morphine dependency.
Materials and Methods : In this study, 60 male mature mice (85 days old) with a weight of 30-35 grams were enrolled as the experimental and the control groups. The experimental groups included 3 subgroups treated with morphine, scopolamine or morphine+ scopolamine, respectively. Morphine was used for dependency and scopolamine for memory attenuation. Conditioned place preference (CCP) method was used to estimate dependency.
Results : Results showed no meaningful difference between the control and the witness groups and between the control and scopolamine groups in preferring a special location to receive the drug. However, there was a meaningful difference (p<0.05) between the control and the morphine groups in preferring a location to receive morphine, and a meaningful attenuation was observed in the scopolamine+morphine group in preferring the location for receiving the drug compared with the group receiving morphine alone.
Conclusion : The results show that through memory attenuation, scopolamine decreases morphine dependent CPP. Binding of scopolamine to muscarinic receptors and blocking them affects the opioid receptors which together with reduced nitric oxide synthesis and decreased intracellular calcium, reduces the morphine-induced CPP.

Keywords

Fulltext

The full text of this article is available on the PDF file.

References

1.
The References of this article are available on the PDF file.

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 1 month ago
Scopus by Title: 0
Last Update: 1 month ago
Scopus by Title (Ref): 1
Last Update: 1 month ago
CrossRef: 0
Last Update: 6 days ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

S. Ebrahim Hosseini:[PubMed][Scholar]

The Official Journal of Zahedan University of Medical Sciences

Outlines

Effect of Memory Attenuation on Creating Morphine Dependency in Male Mature Mice

Abstract

Fulltext

References

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 6 days ago