Fulltext
The full text of this article is available on the PDF file.
Zahedan Journal of Research in Medical Sciences
The Official Journal of Zahedan University of Medical Sciences
e-ISSN 2383-2894
Image Credit:Zahedan J Res Med Sci
Outline
Investigation of the Genes MDR1/MRP1 and Their Relationship with Clinical and Para-Clinical Characteristics of Colorectal Cancer
Authors
1Department of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
2Department of General Surgery, Tehran University of Medical Sciences, Tehran, Iran
3Department of General Surgery, Gastrointestinal and Liver Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding Author: Department of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran Email: frouz@nigeb.ac.ir
Published online:Jan 07, 2013
Article type:Research Article
Received:Jun 11, 2011
Accepted:Oct 22, 2012
How to Cite:Samanian S, Mahjoubi B, Mahjoubi F, Mirzaee R, Azizi R. Investigation of the Genes MDR1/MRP1 and Their Relationship with Clinical and Para-Clinical Characteristics of Colorectal Cancer. Zahedan J Res Med Sci. 2013;15(7):e92926. doi:
Abstract
Background: Resistance to wide range of structurally and functionally different chemotherapy drugs acts as a major obstacle in the cancer therapy. There are different mechanisms that cause multi drug resistance (MDR) but the most important one is ATP Binding Cassette (ABC) transporters super-family that increases the ability of tumor cells to transport drugs out of the cells by using ATP molecule, over expression of these proteins such as MDR1 and MRP1 is responsible for MDR phenotype in cancerous cells. Materials and Methods: We analyzed the expression level of MDR1/MRP1genes by using Real time RT-PCR in 60 colorectal cancer patients also we investigate their relationship with clinical, Para-clinical characterizes of colorectal cancer patients and their responses to treatment. Results: The expression of the MDR1 gene showed a significant increase in cancerous regions compared to adjacent normal tissue. In addition the expression of MDR1 gene showed association with histological grade of tumors but expression level of MRP1 was not significantly important. Conclusion: Our study once more emphasizes the effects of MDR1 over expression which impact on response to drugs in Iranian colorectal cancer patients.
Highlights
References
- 1.The References of this article are available on the PDF file.
Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
20
Nov
2009
Investigation of C3435T Polymorphism in MDR1 Gene of Breast Cancer Patients
Mohsen Taheri,
Frouzandeh Mahjoubi,
Ramesh Omranipour,
Frouzandeh Fereidouni
Taheri M, Mahjoubi F, Omranipour R, Fereidouni F. Investigation of C3435T Polymorphism in MDR1 Gene of Breast Cancer Patients. Zahedan J Res Med Sci. 2009;11(3):e94384. doi:
31
Jan
2020
A Preliminary Study of NER and MMR Pathways Involved in Chemotherapy Response in Bladder Transitional Cell Carcinoma: Impact on progression-free survival
Vahideh Montazeri,
Mohammad Hossein Ghahremani,
Hamed Montazeri,
Mandana Hasanzad,
d, Majid Safavi,
Mohsen Ayati
,et al.Montazeri V, Ghahremani MH, Montazeri H, Hasanzad M, Safavi DM, et al. A Preliminary Study of NER and MMR Pathways Involved in Chemotherapy Response in Bladder Transitional Cell Carcinoma: Impact on progression-free survival. Iran J Pharm Res. 2020;19(1):e124447. doi: https://doi.org/10.22037/ijpr.2020.112646.13878
10
Oct
2014
Verapamil and Rifampin Effect on P-Glycoprotein Expression in Hepatocellular Carcinoma
Amir Jalali,
Sepideh Ghasemian,
Hossein Najafzadeh,
Hamid Galehdari,
Masoud Reza Seifi,
Fateme Zangene
,et al.Jalali A, Ghasemian S, Najafzadeh H, Galehdari H, Seifi MR, et al. Verapamil and Rifampin Effect on P-Glycoprotein Expression in Hepatocellular Carcinoma. Jundishapur J Nat Pharm Prod. 2014;9(4):e17741. doi: https://doi.org/10.17795/jjnpp-17741
25
Nov
2019
Gene Expression of ABCG1, ABCG2, and ABCB1 and Their Role in Iranian Pediatric Patients with Acute Lymphoblastic Leukemia’s Recurrence
Narjes Mehrvar,
Mohammad Reza Rezvany,
Hassan Abolghasemi,
Mohammad Esmaeil Akbari,
Javad Sabery Nejad,
Azim Mehrvar
,et al.Mehrvar N, Rezvany MR, Abolghasemi H, Akbari ME, Sabery Nejad J, et al. Gene Expression of ABCG1, ABCG2, and ABCB1 and Their Role in Iranian Pediatric Patients with Acute Lymphoblastic Leukemia’s Recurrence. Int J Cancer Manag. 2019;12(11):e93300. doi: https://doi.org/10.5812/ijcm.93300
13
Apr
2013
Association Between ABCB1 (MDR1) Gene Polymorphism and Unresponsiveness Combined Therapy in Chronic Hepatitis C virus
Meryem Timucin,
Hakan Alagozlu,
Semra Ozdemir,
Ozturk Ozdemir
Timucin M, Alagozlu H, Ozdemir S, Ozdemir O. Association Between ABCB1 (MDR1) Gene Polymorphism and Unresponsiveness Combined Therapy in Chronic Hepatitis C virus. Hepat Mon. 2013;13(4):e7522. doi: https://doi.org/10.5812/hepatmon.7522
Cited by
- Scopus by DOI: 0
Last Update: 1 week ago
- Scopus by Title: 0
Last Update: 1 week ago
- Scopus by Title (Ref): 1
Last Update: 1 week ago
- CrossRef: 0
Last Update: 4 hours ago
- OpenAlex: 0
Last Update: 7 hours ago
- OpenCitations: 0
Last Update: 5 days ago
Comments
Number of Comments:0